{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang J"],"funding":["Jinling Institute of Science and Technology Ecological Breeding Information Technology Innovation Team","Scientific Research Fund of Jinling Institute of Science and Technology","National Natural Science Foundation of China","Key Discipline of Zootechnics of Jinling Institute of Science and Technology"],"pagination":["2282090"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12674370"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(1)"],"pubmed_abstract":["At various stages of ovarian follicular development, more than 99% of follicles will be eliminated through a degenerative process called atresia. The regulatory mechanisms of atresia have been elucidated to some extent, involving hormones, growth factors, cytokines, and other factors. However, the stimuli initiating atresia in follicular granulosa cells remain unknown. In this study, we isolated the granulosa cells from porcine ovarian follicles (3-5 mm diameter) divided into healthy follicles (HFs) and early atretic follicles (EAFs). We applied high-throughput RNA sequencing to identify and compare differentially expressed genes (DEGs) between HFs and EAFs. A total of 31,694 genes were detected, of which 21,806 were co-expressed in six samples, and 243 genes (<i>p</i> < 0.05; FDR < 0.05) "],"journal":["Animal biotechnology"],"pubmed_title":["Comparative transcriptome profile analysis of granulosa cells from porcine ovarian follicles during early atresia."],"pmcid":["PMC12674370"],"funding_grant_id":["31672421","32002175","31902123",". jit-b-202126"],"pubmed_authors":["Dou Y","Liu J","Pan Z","Zhang J","Wang C","Zhang Y","Qin X","Xu S"],"additional_accession":[]},"is_claimable":false,"name":"Comparative transcriptome profile analysis of granulosa cells from porcine ovarian follicles during early atresia.","description":"At various stages of ovarian follicular development, more than 99% of follicles will be eliminated through a degenerative process called atresia. The regulatory mechanisms of atresia have been elucidated to some extent, involving hormones, growth factors, cytokines, and other factors. However, the stimuli initiating atresia in follicular granulosa cells remain unknown. In this study, we isolated the granulosa cells from porcine ovarian follicles (3-5 mm diameter) divided into healthy follicles (HFs) and early atretic follicles (EAFs). We applied high-throughput RNA sequencing to identify and compare differentially expressed genes (DEGs) between HFs and EAFs. A total of 31,694 genes were detected, of which 21,806 were co-expressed in six samples, and 243 genes (<i>p</i> < 0.05; FDR < 0.05) ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-05T23:42:44.92Z","creation":"2026-05-23T03:13:28.912Z"},"accession":"S-EPMC12674370","cross_references":{"pubmed":["38006572"],"doi":["10.1080/10495398.2023.2282090"]}}