{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McCrimmon CM"],"funding":["Intellectual and Developmental Disabilities Research Center","Simons Foundation","NICHD NIH HHS","NIDA NIH HHS","NIMH NIH HHS","NINDS NIH HHS","National Institutes of Health","Citizens United for Research in Epilepsy","University of California Los Angeles Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research"],"pagination":["116217"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12674601"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(9)"],"pubmed_abstract":["Neurodevelopmental disorders often impair multiple cognitive domains. For instance, a genetic epilepsy syndrome might cause seizures due to cortical hyperexcitability and present with memory impairments arising from hippocampal dysfunction. This study examines how a single disorder differentially affects distinct brain regions using induced pluripotent stem cell (iPSC)-derived cortical- and hippocampal-ganglionic eminence assembloids to model developmental and epileptic encephalopathy 13, a condition arising from gain-of-function mutations in the SCN8A gene encoding the sodium channel Nav1.6. While cortical assembloids showed network hyperexcitability akin to epileptogenic tissue, hippocampal assembloids did not, and instead displayed network dysregulation patterns similar to in vivo hippo"],"journal":["Cell reports"],"pubmed_title":["Cortical versus hippocampal network dysfunction in a human brain assembloid model of epilepsy and intellectual disability."],"pmcid":["PMC12674601"],"funding_grant_id":["R01 DA051897","P50 HD103557","5K08NS119747","717153","K08 NS119747","R01DA051897","R01MH130061","R01 MH130061","49660","P50HD103557","20204012"],"pubmed_authors":["McCrimmon CM","Lin JJ","Toker D","Tidball A","Pahos M","Parent JM","Lozano K","Mody I","Zheng J","Samarasinghe RA","Molnar L","Novitch BG","Cao Q"],"additional_accession":[]},"is_claimable":false,"name":"Cortical versus hippocampal network dysfunction in a human brain assembloid model of epilepsy and intellectual disability.","description":"Neurodevelopmental disorders often impair multiple cognitive domains. For instance, a genetic epilepsy syndrome might cause seizures due to cortical hyperexcitability and present with memory impairments arising from hippocampal dysfunction. This study examines how a single disorder differentially affects distinct brain regions using induced pluripotent stem cell (iPSC)-derived cortical- and hippocampal-ganglionic eminence assembloids to model developmental and epileptic encephalopathy 13, a condition arising from gain-of-function mutations in the SCN8A gene encoding the sodium channel Nav1.6. While cortical assembloids showed network hyperexcitability akin to epileptogenic tissue, hippocampal assembloids did not, and instead displayed network dysregulation patterns similar to in vivo hippo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-05T22:21:24.041Z","creation":"2026-05-22T03:16:23.154Z"},"accession":"S-EPMC12674601","cross_references":{"pubmed":["40925365"],"doi":["10.1016/j.celrep.2025.116217"]}}