{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pinho JS"],"funding":["Generalitat de Catalunya","European Research Council"],"pagination":["RP105863"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12674615"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14"],"pubmed_abstract":["Daily choices are often influenced by environmental cues that are not directly associated with reinforcers. This phenomenon, known as higher-order conditioning, can be studied using sensory preconditioning tasks in rodents. This behavioral paradigm involves the repeated pairing of two innocuous stimuli, such as a light and a tone, followed by a devaluation phase in which one stimulus is associated with an unconditioned stimulus, such as a mild footshock. The result is a conditioned response (e.g., freezing) to both the conditioned stimulus (direct learning) and the non-conditioned stimulus (mediated learning). In our study, we successfully established a light-tone sensory preconditioning task specifically in male mice, as sex differences were observed in both control experimental groups an"],"journal":["eLife"],"pubmed_title":["Dorsal hippocampus mediates light-tone associations in male mice."],"pmcid":["PMC12674615"],"funding_grant_id":["948217","SGR 00022","Jo Investigo Program 2022 INV-1 00005/100005TG3"],"pubmed_authors":["Pinho JS","Manzanares-Sierra I","Busquets-Garcia A","Ramon-Duaso C"],"additional_accession":[]},"is_claimable":false,"name":"Dorsal hippocampus mediates light-tone associations in male mice.","description":"Daily choices are often influenced by environmental cues that are not directly associated with reinforcers. This phenomenon, known as higher-order conditioning, can be studied using sensory preconditioning tasks in rodents. This behavioral paradigm involves the repeated pairing of two innocuous stimuli, such as a light and a tone, followed by a devaluation phase in which one stimulus is associated with an unconditioned stimulus, such as a mild footshock. The result is a conditioned response (e.g., freezing) to both the conditioned stimulus (direct learning) and the non-conditioned stimulus (mediated learning). In our study, we successfully established a light-tone sensory preconditioning task specifically in male mice, as sex differences were observed in both control experimental groups an","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T22:13:56.828Z","creation":"2026-05-22T03:15:27.888Z"},"accession":"S-EPMC12674615","cross_references":{"pubmed":["41334885"],"doi":["10.7554/eLife.105863"]}}