{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["648(8092)"],"submitter":["Yang HC"],"pubmed_abstract":["Han Chinese people comprise nearly 20% of the global population but remain under-represented in genetic studies<sup>1,2</sup>, so there is an urgent need for large-scale cohorts to advance precision medicine. Here we present the Taiwan Precision Medicine Initiative (TPMI), established by Academia Sinica in collaboration with 16 major medical centres around Taiwan, which has recruited 565,390 participants who consent to provide DNA samples for genetic profiling and grant access to their electronic medical records (EMRs) for research. EMR access is both retrospective and prospective, allowing longitudinal studies. Genetic profiling is done with population-optimized arrays of single-nucleotide polymorphisms for people of Han Chinese ancestry, which enable genome-wide association<sup>3,4</sup>"],"journal":["Nature"],"pagination":["117-127"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12675286"],"repository":["biostudies-literature"],"pubmed_title":["The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies."],"pmcid":["PMC12675286"],"pubmed_authors":["Lin MH","Chen PY","Huang WT","Pang ST","Chen YC","Chen HH","Hang JF","Sheu WH","Kwok PY","Lin EP","Liu YM","Yang JH","Chang SJ","Tsai MH","Sung YF","Yeh EC","Tsai MF","Chen PC","Sin J","Yao WJ","Hwang JJ","Yen KY","Wu CS","Wang YK","Lin CY","Yang SS","Chen WM","Chiu TF","Tung H","Yang SF","Chen WL","Jiang JY","Tsui K","Chan YJ","Wu CC","Yen TT","Lee TH","Chiou JF","Tseng WC","Lee KY","Wei CY","Tsai JR","Wu JY","Yang HC","Chien CC","Yang YH","Lee SL","Hsieh YC","Liu IL","Fang YJ","Chang TY","Hu TH","Chao KK","Fann CS","Yeh YC","Kuo YJ","Chang LP","Chang LC","Yu PP","Wu YW","Li LH","Mao CL","Wang CH","Tseng LM","Wu YM","Wang TF","Chou TY","Yang FC","Chen CY","Wang LC","Chiang CY","Chiu HY","Chen TC","Chen CW","Li KJ","Ma GC","Shih CM","Cheng CK","Hsieh SC","Kao KJ","Chu SJ","Chen M","Lai CH","Jong YJ","Lee YL","Chen SS","Liou TH","Chen CC","Lee YJ","Chu SK","Chen CH","Kan K","Chang FP","Wang DW","Ho HL","Chong IW","Huang CY","Yen HC","Hung CF","Chen SA","Hsiao TH","Yang CS","Chuang HP","Chiu CH","Shyu YC","Chiu KM","Liu FC","Wu WJ","Chiang FT","Liang WY","Tseng SH","Liao YJ","Ho CH","Lin SZ","Cherng YG","Lin CH","Huang YT","Lin SY","Kuo CH","Yu MC","Chang YL","Hou MF","Hou MC","Lee WJ","Ou YC","Chang HT","Pan CC","Tsai HL","Lin SC","Chen YT","Chen IC","Wu MS","Chen YJ","Sheen YJ","Chen YM","Huang JF","Chang HA"],"additional_accession":[]},"is_claimable":false,"name":"The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies.","description":"Han Chinese people comprise nearly 20% of the global population but remain under-represented in genetic studies<sup>1,2</sup>, so there is an urgent need for large-scale cohorts to advance precision medicine. Here we present the Taiwan Precision Medicine Initiative (TPMI), established by Academia Sinica in collaboration with 16 major medical centres around Taiwan, which has recruited 565,390 participants who consent to provide DNA samples for genetic profiling and grant access to their electronic medical records (EMRs) for research. EMR access is both retrospective and prospective, allowing longitudinal studies. Genetic profiling is done with population-optimized arrays of single-nucleotide polymorphisms for people of Han Chinese ancestry, which enable genome-wide association<sup>3,4</sup>","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-15T12:25:15.675Z","creation":"2026-07-04T03:12:58.105Z"},"accession":"S-EPMC12675286","cross_references":{"pubmed":["41092961"],"doi":["10.1038/s41586-025-09680-x"]}}