biostudies-literatureUnknown16Cheng WJ<h4>Introduction</h4>There is considerable potential for using Chinese Herbal Medicine to manage inflammatory co-morbidities, including cardiovascular disease, in people with HIV. However, any use would require understanding herb-drug interactions with antiretroviral (ARV) drugs to ensure safety. We evaluate evidence for the effect of selected cardioprotective Chinese herbs on the activity of cytochrome P450 (CYP) enzymes that metabolise ARV drugs.<h4>Methods</h4>We conducted a comprehensive review of six Chinese herbs commonly found in Chinese herbal formulas for treating cardiovascular conditions. We examined the effects of their extracts and reference bioactive molecules on CYP expression and enzymatic activity. The review focused on evidence from <i>in vitro</i> laboratory studies. TheFrontiers in pharmacology1627058https://www.ebi.ac.uk/biostudies/studies/S-EPMC12675451biostudies-literatureCardioprotective Chinese herbs and antiretroviral drug metabolism: a systematic review of in vitro evidence.PMC12675451Xue CCTrevillyan JMJaworowski ACheng WJHearps ACZhang ALfalseCardioprotective Chinese herbs and antiretroviral drug metabolism: a systematic review of in vitro evidence.<h4>Introduction</h4>There is considerable potential for using Chinese Herbal Medicine to manage inflammatory co-morbidities, including cardiovascular disease, in people with HIV. However, any use would require understanding herb-drug interactions with antiretroviral (ARV) drugs to ensure safety. We evaluate evidence for the effect of selected cardioprotective Chinese herbs on the activity of cytochrome P450 (CYP) enzymes that metabolise ARV drugs.<h4>Methods</h4>We conducted a comprehensive review of six Chinese herbs commonly found in Chinese herbal formulas for treating cardiovascular conditions. We examined the effects of their extracts and reference bioactive molecules on CYP expression and enzymatic activity. The review focused on evidence from <i>in vitro</i> laboratory studies. The2025-01-01T00:00:00Z20252026-05-23T03:24:51.389Z2026-05-23T03:13:37.142ZS-EPMC126754514135785810.3389/fphar.2025.1627058