{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Baral S"],"funding":["National Institute of Allergy and Infectious Diseases","NIGMS NIH HHS"],"pagination":["521-537"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12675982"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["124(6)"],"pubmed_abstract":["By regulating the assortment and abundance of its virulence factors at different anatomic sites, the group A Streptococcus (GAS) can cause a range of human diseases. The Fas regulatory system is encoded by a four-gene locus, fasBCAX, with fasX encoding the FasX small regulatory RNA effector molecule. FasX post-transcriptionally regulates target mRNAs through well-characterized mechanisms. Less characterized are the layers of regulation that occur upstream of FasX activity, such as how the products of the fasBCA genes enhance FasX abundance 100-fold. Here, we present data consistent with FasBCA forming a three-component regulatory system, with FasBC being sensor kinase-like proteins that, upon recognizing one or more signals, heterodimerize and phosphorylate FasA, with phosphorylated FasA b"],"journal":["Molecular microbiology"],"pubmed_title":["Molecular Characterization of the Group A Streptococcus Virulence-Regulatory System FasBCAX."],"pmcid":["PMC12675982"],"funding_grant_id":["R21AI163230","GM103440"],"pubmed_authors":["Prabhu A","Roshika R","Woolsey R","Baral S","Tal-Gan Y","Sumby P","Singh A","Jain I","Quilici D","Renshaw CP"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Characterization of the Group A Streptococcus Virulence-Regulatory System FasBCAX.","description":"By regulating the assortment and abundance of its virulence factors at different anatomic sites, the group A Streptococcus (GAS) can cause a range of human diseases. The Fas regulatory system is encoded by a four-gene locus, fasBCAX, with fasX encoding the FasX small regulatory RNA effector molecule. FasX post-transcriptionally regulates target mRNAs through well-characterized mechanisms. Less characterized are the layers of regulation that occur upstream of FasX activity, such as how the products of the fasBCA genes enhance FasX abundance 100-fold. Here, we present data consistent with FasBCA forming a three-component regulatory system, with FasBC being sensor kinase-like proteins that, upon recognizing one or more signals, heterodimerize and phosphorylate FasA, with phosphorylated FasA b","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T22:18:15.785Z","creation":"2026-05-22T03:15:27.013Z"},"accession":"S-EPMC12675982","cross_references":{"pubmed":["41108551"],"doi":["10.1111/mmi.70029"]}}