biostudies-literatureBray GRosetrees TrustMitchell Charitable TrustEuropean Union Seventh Framework ProgrammeSeventh Framework ProgrammeNational Institute for Health and Care Research61-70https://www.ebi.ac.uk/biostudies/studies/S-EPMC12676201biostudies-literatureUnknown133(1)<h4>Objective</h4>Foetal growth restriction (FGR) affects 10% of pregnancies, contributing to 30% of stillbirths. Current management of early-onset FGR (< 32 + 0 weeks' gestation) delivers the foetus before stillbirth or irreversible organ damage. The resulting preterm births create additional risks independent of FGR. We determined the economic cost associated with severe early-onset FGR.<h4>Design</h4>Economic analysis of EVERREST prospective study, a 6-year multicentre prospective cohort study.<h4>Setting</h4>UK, Spain, Germany, Sweden.<h4>Population</h4>Pregnant women with estimated foetal weight < 3rd centile, 20 + 0-26 + 6 weeks of gestation.<h4>Methods</h4>Between antenatal recruitment and 2 years post-delivery, maternal and infant resource use was collected using the Global PregnanBJOG : an international journal of obstetrics and gynaecologyEconomic Impact of Severe Early-Onset Foetal Growth Restriction: A Multicentre Prospective Cohort Study.PMC12676201305823Gratacos EMaksym KMarlow NHansson SRSpencer RNGinsberg YHunter RDavid ALWeissbach THuertas-Ceballos ADilipkumar MFigueras FCrispi FBuquis GOkell JHecher KDiemert APeebles DMLey DBray GSinger DfalseEconomic Impact of Severe Early-Onset Foetal Growth Restriction: A Multicentre Prospective Cohort Study.<h4>Objective</h4>Foetal growth restriction (FGR) affects 10% of pregnancies, contributing to 30% of stillbirths. Current management of early-onset FGR (< 32 + 0 weeks' gestation) delivers the foetus before stillbirth or irreversible organ damage. The resulting preterm births create additional risks independent of FGR. We determined the economic cost associated with severe early-onset FGR.<h4>Design</h4>Economic analysis of EVERREST prospective study, a 6-year multicentre prospective cohort study.<h4>Setting</h4>UK, Spain, Germany, Sweden.<h4>Population</h4>Pregnant women with estimated foetal weight < 3rd centile, 20 + 0-26 + 6 weeks of gestation.<h4>Methods</h4>Between antenatal recruitment and 2 years post-delivery, maternal and infant resource use was collected using the Global Pregnan2026-01-01T00:00:00Z2026 Jan2026-06-05T22:20:59.192Z2026-05-22T03:16:16.952ZS-EPMC126762014055242210.1111/1471-0528.18266