{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(47)"],"submitter":["Aphrham S"],"pubmed_abstract":["Precise localization of biomarkers within the sensing area of biosensors is crucial for enhancing performance and minimizing analyte loss to nonsensing regions. Commercial material-selective coatings enable site-specific biofunctionalization but are typically constrained by limited reactive chemistries, reducing their versatility and controllability. We present a selective coating strategy based on a poly-l-lysine (PLL) scaffold that retains the material-selective properties of a commercial carboxylic acid (COOH)-based coating for a Si<sub>3</sub>N<sub>4</sub> waveguide with a poly-(ethylene glycol) (PEG)-covered SiO<sub>2</sub> surrounding while enabling modular surface functionalization. The PLL scaffold was functionalized with controlled grafting densities of oligo-(ethylene glycol) (OE"],"journal":["ACS omega"],"pagination":["57674-57683"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12676348"],"repository":["biostudies-literature"],"pubmed_title":["Material-Selective Deposition of Reactive Group-Functionalized Poly‑l‑lysine for DNA Sensing at Optical Waveguides."],"pmcid":["PMC12676348"],"pubmed_authors":["Huskens J","Aphrham S","Verheijden M"],"additional_accession":[]},"is_claimable":false,"name":"Material-Selective Deposition of Reactive Group-Functionalized Poly‑l‑lysine for DNA Sensing at Optical Waveguides.","description":"Precise localization of biomarkers within the sensing area of biosensors is crucial for enhancing performance and minimizing analyte loss to nonsensing regions. Commercial material-selective coatings enable site-specific biofunctionalization but are typically constrained by limited reactive chemistries, reducing their versatility and controllability. We present a selective coating strategy based on a poly-l-lysine (PLL) scaffold that retains the material-selective properties of a commercial carboxylic acid (COOH)-based coating for a Si<sub>3</sub>N<sub>4</sub> waveguide with a poly-(ethylene glycol) (PEG)-covered SiO<sub>2</sub> surrounding while enabling modular surface functionalization. The PLL scaffold was functionalized with controlled grafting densities of oligo-(ethylene glycol) (OE","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T23:31:13.041Z","creation":"2026-05-23T03:13:47.732Z"},"accession":"S-EPMC12676348","cross_references":{"pubmed":["41358075"],"doi":["10.1021/acsomega.5c09098"]}}