{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(12)"],"submitter":["Paluri S"],"pubmed_abstract":["Cellular permeability barriers restrict the diffusion of solutes, pathogens, and cells across tissues. In Drosophila melanogaster, septate and tricellular junctions create permeability barriers in epithelia and the blood-brain barrier in glia. In vitro, and in vivo studies in the epithelia of the Drosophila wing imaginal discs identified microRNA-184 (miR-184) as a potential regulator of a subset of pleated septate and tricellular junction proteins. However, which tissues express miR-184, and the consequences of miR-184 expression on the blood-brain barrier has not been examined. Using a miR-184 sensor, we found that miR-184 is absent in tissues with pleated septate junctions but is present in tissues with smooth septate junctions. When expressed in the subperineurial glia that form the bl"],"journal":["PloS one"],"pagination":["e0328862"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12677480"],"repository":["biostudies-literature"],"pubmed_title":["microRNA-184 distribution and consequences on glial septate junctions and the blood-brain barrier."],"pmcid":["PMC12677480"],"pubmed_authors":["Auld VJ","Paluri S"],"additional_accession":[]},"is_claimable":false,"name":"microRNA-184 distribution and consequences on glial septate junctions and the blood-brain barrier.","description":"Cellular permeability barriers restrict the diffusion of solutes, pathogens, and cells across tissues. In Drosophila melanogaster, septate and tricellular junctions create permeability barriers in epithelia and the blood-brain barrier in glia. In vitro, and in vivo studies in the epithelia of the Drosophila wing imaginal discs identified microRNA-184 (miR-184) as a potential regulator of a subset of pleated septate and tricellular junction proteins. However, which tissues express miR-184, and the consequences of miR-184 expression on the blood-brain barrier has not been examined. Using a miR-184 sensor, we found that miR-184 is absent in tissues with pleated septate junctions but is present in tissues with smooth septate junctions. When expressed in the subperineurial glia that form the bl","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-07-15T13:51:48.373Z","creation":"2026-07-05T03:11:29.666Z"},"accession":"S-EPMC12677480","cross_references":{"pubmed":["41343484"],"doi":["10.1371/journal.pone.0328862"]}}