{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mao C"],"funding":["National Key R&D Program of China","National Science Fund for Distinguished Youth Scholar","General Research Fund of Hong Kong Research Grant Council","Shenzhen Science and Technology Funding","Hong Kong Health and Medical Research Fund","National Key Research and Development Program of China"],"pagination":["e05748"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12677624"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(45)"],"pubmed_abstract":["Reactive oxygen species (ROS) are a promising alternative bactericide. However, it is questioned that bacteria can potentially develop resistance to ROS, similar to their resistance against antibiotics and silver. Herein, it is reported that Gram-negative bacteria, including Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae, develop resistance to ROS after six repeated exposures. Notably, ROS minimum inhibitory concentration of Pseudomonas aeruginosa significantly increases to 256-fold after ten passages. The resistance mechanism predominantly originates from the intensified biosynthesis of the highly reductive hydrogen sulfide (H<sub>2</sub>S) and pyoverdine (PVD) siderophores, effectively neutralizing ROS. Simultaneously, PVD transports Fe<sup>3+</sup> from the extracel"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Biosynthesis of H&lt;sub&gt;2&lt;/sub&gt;S and Siderophores Targeting Gram-Negative Bacterial Resistance to Reactive Oxygen Species."],"pmcid":["PMC12677624"],"funding_grant_id":["21200592","23220952","20190422","23220752","51925104","JCYJ20210324120012034","22210832","JCYJ20210324120009026","17111322","2023YFB3810200"],"pubmed_authors":["Liu X","Qiao W","Wu J","Jin W","Mao C","Zhu Y","Wu S","Xiang Y","Cheung KMC","Yeung KWK"],"additional_accession":[]},"is_claimable":false,"name":"Biosynthesis of H&lt;sub&gt;2&lt;/sub&gt;S and Siderophores Targeting Gram-Negative Bacterial Resistance to Reactive Oxygen Species.","description":"Reactive oxygen species (ROS) are a promising alternative bactericide. However, it is questioned that bacteria can potentially develop resistance to ROS, similar to their resistance against antibiotics and silver. Herein, it is reported that Gram-negative bacteria, including Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae, develop resistance to ROS after six repeated exposures. Notably, ROS minimum inhibitory concentration of Pseudomonas aeruginosa significantly increases to 256-fold after ten passages. The resistance mechanism predominantly originates from the intensified biosynthesis of the highly reductive hydrogen sulfide (H<sub>2</sub>S) and pyoverdine (PVD) siderophores, effectively neutralizing ROS. Simultaneously, PVD transports Fe<sup>3+</sup> from the extracel","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T23:09:32.068Z","creation":"2026-05-23T03:13:29.692Z"},"accession":"S-EPMC12677624","cross_references":{"pubmed":["40948366"],"doi":["10.1002/advs.202505748"]}}