biostudies-literatureYuan QHubei Province Postdoctoral Innovative Talent Training ProgramNational Natural Science Foundation of ChinaInnovation and Development Joint Fund of EnshiKey Research and Development Program of Hubei Provincee01233https://www.ebi.ac.uk/biostudies/studies/S-EPMC12677672biostudies-literatureUnknown12(45)Cellular senescence is a hallmark of aging and the accumulation of senescent cells (SnCs) accelerates the aging process, contributing to aging-related organ disorders. The PRDF1 and RIZ1 homology domain (PRDM) protein exhibits robust transcriptional regulatory activities and governs a wide range of biological processes. However, its roles in cellular senescence remain unclear. Here, this work demonstrates that PRDM16, a member of the PRDM protein family, decreases significantly in multiple organs of aged mice compared to young mice. Global Prdm16 deletion contributes to cellular senescence in various organs, including the kidneys, heart, lungs, hippocampus, stomach, and gut, leading to accelerated aging-related organ injury. Furthermore, tubular-specific Prdm16 deletion aggravates irradiatAdvanced science (Weinheim, Baden-Wurttemberg, Germany)PRDM16 Reduces Cellular Senescence by Upregulating GSTM1.PMC1267767282300851823008432024HBBHCXB0288197409782300786821007948180061082470771822008088237072882100729821707732023BCB034822008412024AFD083Liu YXie YZhu YYuan QHu MTang BZhang CSu HfalsePRDM16 Reduces Cellular Senescence by Upregulating GSTM1.Cellular senescence is a hallmark of aging and the accumulation of senescent cells (SnCs) accelerates the aging process, contributing to aging-related organ disorders. The PRDF1 and RIZ1 homology domain (PRDM) protein exhibits robust transcriptional regulatory activities and governs a wide range of biological processes. However, its roles in cellular senescence remain unclear. Here, this work demonstrates that PRDM16, a member of the PRDM protein family, decreases significantly in multiple organs of aged mice compared to young mice. Global Prdm16 deletion contributes to cellular senescence in various organs, including the kidneys, heart, lungs, hippocampus, stomach, and gut, leading to accelerated aging-related organ injury. Furthermore, tubular-specific Prdm16 deletion aggravates irradiat2025-01-01T00:00:00Z2025 Dec2026-06-05T22:24:29.275Z2026-05-22T03:15:58.887ZS-EPMC126776724094618310.1002/advs.202501233