biostudies-literatureUnknown20(12)Saunders N<h4>Background</h4>The marked heterogeneity of Amyotrophic Lateral Sclerosis (ALS) combined with a lack of biomarkers are key contributing factors to the lack of disease-modifying treatments. The Comprehensive Analysis Platform to Understand Remedy and Eliminate ALS (CAPTURE ALS) is a Canadian platform designed to create the most comprehensive picture of people living with ALS with the objective of facilitating ALS research initiatives worldwide.<h4>Objectives</h4>The main aims of CAPTURE ALS include: (1) to characterize ALS and healthy controls with biosamples and data in order to provide the most comprehensive picture of individuals living with ALS to date; (2) to create a de-identified database and biosample repository linked to detailed clinical information; and (3) to develop and implPloS onee0332430https://www.ebi.ac.uk/biostudies/studies/S-EPMC12677780biostudies-literatureComprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study.PMC12677780Abrahao AMedina YILuth WTremblay-Desbiens CMagnussen CDas SMatte GSaunders NAbou-Haidar RGenuis SKKriz JKang HTaylor DYunusova YBubela TGenge AZinman LBowser RJohnston WSJones KEKaramchandani JVelde CVBlais MFerry NEvans ARogaeva EDhanoa ABouvier LGraham SJPfeffer GBoivin MNAnand TSeres PTam FDupre NFrater YKalra SChiappini JRobertson JBhinder HGreiner RfalseComprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study.<h4>Background</h4>The marked heterogeneity of Amyotrophic Lateral Sclerosis (ALS) combined with a lack of biomarkers are key contributing factors to the lack of disease-modifying treatments. The Comprehensive Analysis Platform to Understand Remedy and Eliminate ALS (CAPTURE ALS) is a Canadian platform designed to create the most comprehensive picture of people living with ALS with the objective of facilitating ALS research initiatives worldwide.<h4>Objectives</h4>The main aims of CAPTURE ALS include: (1) to characterize ALS and healthy controls with biosamples and data in order to provide the most comprehensive picture of individuals living with ALS to date; (2) to create a de-identified database and biosample repository linked to detailed clinical information; and (3) to develop and impl2025-01-01T00:00:00Z20252026-06-05T23:19:47.465Z2026-05-23T03:13:55.254ZS-EPMC126777804134358210.1371/journal.pone.0332430