biostudies-literatureUnknown16Feng YLNephropathy refers to a wide range of kidney dysfunction and is a highly prevalent condition worldwide, often associated with several disorders, including inflammation, oxidative stress, apoptosis, epithelial-mesenchymal transition (EMT), autophagy, and the deposition of extracellular matrix (ECM). Licorice has been used in China for thousands of years to treat nephropathy, while the underlying mechanisms are still unclear. The triterpenoid and flavonoid compounds are the main components of licorice. The main bioactive components of licorice against nephropathy are glycyrrhizic acid, glycyrrhetinic acid, isoliquiritigenin, glabridin, isoliquiritin and licochalcone A. These components alleviate kidney injury through anti-inflammatory, anti-oxidative stress, anti-apoptosis, promoting autophaFrontiers in pharmacology1672643https://www.ebi.ac.uk/biostudies/studies/S-EPMC12678090biostudies-literatureLicorice in nephropathy treatment: phytochemical compositions and pharmacological mechanisms.PMC12678090Feng YLWang YNShui LChen LWang WBChen HJiang YXfalseLicorice in nephropathy treatment: phytochemical compositions and pharmacological mechanisms.Nephropathy refers to a wide range of kidney dysfunction and is a highly prevalent condition worldwide, often associated with several disorders, including inflammation, oxidative stress, apoptosis, epithelial-mesenchymal transition (EMT), autophagy, and the deposition of extracellular matrix (ECM). Licorice has been used in China for thousands of years to treat nephropathy, while the underlying mechanisms are still unclear. The triterpenoid and flavonoid compounds are the main components of licorice. The main bioactive components of licorice against nephropathy are glycyrrhizic acid, glycyrrhetinic acid, isoliquiritigenin, glabridin, isoliquiritin and licochalcone A. These components alleviate kidney injury through anti-inflammatory, anti-oxidative stress, anti-apoptosis, promoting autopha2025-01-01T00:00:00Z20252026-06-05T23:35:15.922Z2026-05-23T03:13:54.536ZS-EPMC126780904135789210.3389/fphar.2025.1672643