{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Zhang X"],"pubmed_abstract":["The M protein located on the surface of group A <i>Streptococcus</i> has been extensively researched as a promising vaccine candidate. However, issues such as potential cross-reactivity with human tissues and the impact of selection of M peptide sequences have raised concerns regarding the safety and efficacy of the M protein vaccine. In this study, we utilized a KSI (ketosteroid isomerase, 15.78 kDa) tag and conducted a comparative analysis of the N-terminal (M12-N, 28.14 kDa), C-terminal (M12-C, 30.24 kDa), and fusion form (M12-N+C, 29.19 kDa) derived from the M12 protein found in MGAS9429. Three vaccine candidates formulated with aluminum hydroxide adjuvant significantly increased specific antibody titers in serum following booster immunization. Furthermore, immunization with these vacc"],"journal":["Frontiers in immunology"],"pagination":["1636591"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12678301"],"repository":["biostudies-literature"],"pubmed_title":["Immunization with the M12-N, M12-C, and M12-N+C fusion peptides derived from the M12 protein elicited varying levels of protective immune responses against multiple serotypes of group A &lt;i&gt;Streptococcus&lt;/i&gt;."],"pmcid":["PMC12678301"],"pubmed_authors":["Na R","Zhou Q","Zhang X","Ma Y","Hanski E","Hou W"],"additional_accession":[]},"is_claimable":false,"name":"Immunization with the M12-N, M12-C, and M12-N+C fusion peptides derived from the M12 protein elicited varying levels of protective immune responses against multiple serotypes of group A &lt;i&gt;Streptococcus&lt;/i&gt;.","description":"The M protein located on the surface of group A <i>Streptococcus</i> has been extensively researched as a promising vaccine candidate. However, issues such as potential cross-reactivity with human tissues and the impact of selection of M peptide sequences have raised concerns regarding the safety and efficacy of the M protein vaccine. In this study, we utilized a KSI (ketosteroid isomerase, 15.78 kDa) tag and conducted a comparative analysis of the N-terminal (M12-N, 28.14 kDa), C-terminal (M12-C, 30.24 kDa), and fusion form (M12-N+C, 29.19 kDa) derived from the M12 protein found in MGAS9429. Three vaccine candidates formulated with aluminum hydroxide adjuvant significantly increased specific antibody titers in serum following booster immunization. Furthermore, immunization with these vacc","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-05T23:39:48.038Z","creation":"2026-05-23T03:14:00.688Z"},"accession":"S-EPMC12678301","cross_references":{"pubmed":["41357204"],"doi":["10.3389/fimmu.2025.1636591"]}}