biostudies-literatureUnknown167(1)Aboubakr O<h4>Background</h4>Laser Interstitial Thermal Therapy (LITT) is a minimally invasive option for treating epilepsy and neuro-oncologic lesions, including those deemed inoperable. However, it does not allow for histomolecular diagnosis.<h4>Methods</h4>We describe our technique for combining stereotactic brain biopsy and LITT, focusing on biopsy sample quantity and its effects on MRI thermometry and ablation quality.<h4>Conclusion</h4>Stereotactic biopsy can be safely integrated with LITT. Limiting sampling to two specimens minimizes air diffusion and hemorrhagic risk, reducing thermometric artifacts and preserving the accuracy of ablation.Acta neurochirurgica312https://www.ebi.ac.uk/biostudies/studies/S-EPMC12678548biostudies-literatureHow I do it: sequential robot-assisted stereotactic biopsy and laser interstitial thermal therapy for epilepsy associated with brain tumors.PMC12678548Aboubakr OMathon BfalseHow I do it: sequential robot-assisted stereotactic biopsy and laser interstitial thermal therapy for epilepsy associated with brain tumors.<h4>Background</h4>Laser Interstitial Thermal Therapy (LITT) is a minimally invasive option for treating epilepsy and neuro-oncologic lesions, including those deemed inoperable. However, it does not allow for histomolecular diagnosis.<h4>Methods</h4>We describe our technique for combining stereotactic brain biopsy and LITT, focusing on biopsy sample quantity and its effects on MRI thermometry and ablation quality.<h4>Conclusion</h4>Stereotactic biopsy can be safely integrated with LITT. Limiting sampling to two specimens minimizes air diffusion and hemorrhagic risk, reducing thermometric artifacts and preserving the accuracy of ablation.2025-01-01T00:00:00Z2025 Dec2026-05-22T03:25:30.018Z2026-05-22T03:16:07.255ZS-EPMC126785484133960010.1007/s00701-025-06705-2