biostudies-literatureUnknown5(6)Guarducci MAA novel copper-(I)-anchored covalent organic polymer (Cu⁺@COP) is presented as a robust, heterogeneous catalyst for copper-catalyzed azide-alkyne cycloaddition (CuAAC), operating without the need for external reducing agents or observable copper leaching. Cu⁺ stabilization is achieved via multidentate N,O-ligand coordination within the polymer matrix, enabling high catalytic efficiency (up to 95% yield) and recyclability. Structural, spectroscopic, and ICP-OES analyses confirm Cu presence, offering an alternative to traditional CuAAC protocols. This system combines operational simplicity, reduced waste, and green chemistry principles, positioning Cu⁺@COP as a practical catalyst for applications in synthetic and materials chemistry.ACS organic & inorganic Au507-517https://www.ebi.ac.uk/biostudies/studies/S-EPMC12679302biostudies-literatureCopper(I)-Anchoring Covalent Organic Polymer for Heterogeneous CuAAC Reaction without Reducing Agents and Copper Leaching.PMC12679302Manetto SGuarducci MAVillani CAmato FFontana APilato SCiogli AColuccia MMarrani AGGuglielmi PMazzoccanti GfalseCopper(I)-Anchoring Covalent Organic Polymer for Heterogeneous CuAAC Reaction without Reducing Agents and Copper Leaching.A novel copper-(I)-anchored covalent organic polymer (Cu⁺@COP) is presented as a robust, heterogeneous catalyst for copper-catalyzed azide-alkyne cycloaddition (CuAAC), operating without the need for external reducing agents or observable copper leaching. Cu⁺ stabilization is achieved via multidentate N,O-ligand coordination within the polymer matrix, enabling high catalytic efficiency (up to 95% yield) and recyclability. Structural, spectroscopic, and ICP-OES analyses confirm Cu presence, offering an alternative to traditional CuAAC protocols. This system combines operational simplicity, reduced waste, and green chemistry principles, positioning Cu⁺@COP as a practical catalyst for applications in synthetic and materials chemistry.2025-01-01T00:00:00Z2025 Dec2026-06-05T23:27:20.599Z2026-05-23T03:13:32.905ZS-EPMC126793024135644510.1021/acsorginorgau.5c00067