biostudies-literatureUnknown8(12)Singier A<h4>Importance</h4>Although pharmacovigilance signals and a strong pathophysiological rationale have suggested a potential risk of arterial dissections or aneurysms associated with angiogenesis inhibitors, this association deserves to be further investigated through clinical practice evidence studies.<h4>Objective</h4>To evaluate the association between exposure to angiogenesis inhibitors and the occurrence of arterial dissections or aneurysms in patients treated for metastatic colorectal cancer (mCRC).<h4>Design, setting, and participants</h4>A nested case-control study was conducted within a cohort of adults initiating targeted therapy (angiogenesis or epidermal growth factor receptor inhibitors) for mCRC between January 1, 2012, and December 31, 2017. Data were analyzed from April 2021 JAMA network opene2546960https://www.ebi.ac.uk/biostudies/studies/S-EPMC12679322biostudies-literatureAngiogenesis Inhibitors and Arterial Dissection or Aneurysm in Patients With Metastatic Colorectal Cancer.PMC12679322Jarne Munoz APariente ANoize PMaumus-Robert SSingier ABerard XBezin JKempf EfalseAngiogenesis Inhibitors and Arterial Dissection or Aneurysm in Patients With Metastatic Colorectal Cancer.<h4>Importance</h4>Although pharmacovigilance signals and a strong pathophysiological rationale have suggested a potential risk of arterial dissections or aneurysms associated with angiogenesis inhibitors, this association deserves to be further investigated through clinical practice evidence studies.<h4>Objective</h4>To evaluate the association between exposure to angiogenesis inhibitors and the occurrence of arterial dissections or aneurysms in patients treated for metastatic colorectal cancer (mCRC).<h4>Design, setting, and participants</h4>A nested case-control study was conducted within a cohort of adults initiating targeted therapy (angiogenesis or epidermal growth factor receptor inhibitors) for mCRC between January 1, 2012, and December 31, 2017. Data were analyzed from April 2021 2025-01-01T00:00:00Z2025 Dec2026-06-05T22:34:40.873Z2026-05-23T03:08:48.616ZS-EPMC126793224134321010.1001/jamanetworkopen.2025.46960