{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(3)"],"submitter":["Wang W"],"pubmed_abstract":["<b>Rationale:</b> The tumor microenvironment (TME), which is characterized by disordered metabolism, acidic pH, and high glutathione (GSH) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) levels, seriously hampers the efficacy of cancer therapy. Nanozymes with multi-enzyme activity have considerable potential to reprogram the TME and suppress tumor growth. <b>Methods:</b> A strategy for remodulating the TME based on a hierarchical CuO nanozyme with oxygen vacancies decorated with hyaluronic acid (HA) (CuO@HA) was developed. The enzyme activities of CuO@HA were evaluated by enzyme kinetic assays and density functional theory (DFT). The <i>in vitro</i> and <i>in vivo</i> anti-tumor effects were estimated, and the mechanism was explored using multi-omic methods. <b>Results:</b> CuO@HA exhib"],"journal":["Theranostics"],"pagination":["1374-1385"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12679366"],"repository":["biostudies-literature"],"pubmed_title":["Synergistic chemodynamic and metabolic reprogramming-based cancer therapy by CuO@HA nanozymes with oxygen vacancy."],"pmcid":["PMC12679366"],"pubmed_authors":["Yoon J","Hu T","Feng M","Jia Y","Cai Y","Wang W","Song H","Hu Q","Wang Y","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Synergistic chemodynamic and metabolic reprogramming-based cancer therapy by CuO@HA nanozymes with oxygen vacancy.","description":"<b>Rationale:</b> The tumor microenvironment (TME), which is characterized by disordered metabolism, acidic pH, and high glutathione (GSH) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) levels, seriously hampers the efficacy of cancer therapy. Nanozymes with multi-enzyme activity have considerable potential to reprogram the TME and suppress tumor growth. <b>Methods:</b> A strategy for remodulating the TME based on a hierarchical CuO nanozyme with oxygen vacancies decorated with hyaluronic acid (HA) (CuO@HA) was developed. The enzyme activities of CuO@HA were evaluated by enzyme kinetic assays and density functional theory (DFT). The <i>in vitro</i> and <i>in vivo</i> anti-tumor effects were estimated, and the mechanism was explored using multi-omic methods. <b>Results:</b> CuO@HA exhib","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-06-10T04:52:44.759Z","creation":"2026-06-10T03:07:11.033Z"},"accession":"S-EPMC12679366","cross_references":{"pubmed":["41355969"],"doi":["10.7150/thno.119806"]}}