biostudies-literatureUnknown14(23)Harada GK<h4>Background</h4>The relative benefit of neoadjuvant therapies remains controversial for patients with (borderline) resectable pancreatic ductal adenocarcinoma (PDAC). The purpose of this study was to create a model to predict response to multiagent neoadjuvant chemotherapy (NAC) followed by radiotherapy with elective nodal irradiation (ENI).<h4>Methods</h4>Using the National Cancer Database (NCDB), we identified patients with cT1-4N0M0 PDAC diagnosed between 2006 and 2020 treated with multiagent NAC, radiation with ENI, followed by curative resection with nodal dissection. A LASSO logistic regression model was used to predict ypN0 status, with generation of a nomogram and assessment of outcomes in training and testing cohorts. Secondary endpoints of negative-margin resection and overallCancer medicinee71447https://www.ebi.ac.uk/biostudies/studies/S-EPMC12679486biostudies-literaturePredicting Benefit of Neoadjuvant Chemotherapy and Elective Nodal Irradiation in Pancreatic Adenocarcinoma: A Supervised Machine Learning Approach.PMC12679486Seyedin SNDayyani FHarada GKPark JImagawa DJutric ZPeterson NHong DSMunjal AValerin JfalsePredicting Benefit of Neoadjuvant Chemotherapy and Elective Nodal Irradiation in Pancreatic Adenocarcinoma: A Supervised Machine Learning Approach.<h4>Background</h4>The relative benefit of neoadjuvant therapies remains controversial for patients with (borderline) resectable pancreatic ductal adenocarcinoma (PDAC). The purpose of this study was to create a model to predict response to multiagent neoadjuvant chemotherapy (NAC) followed by radiotherapy with elective nodal irradiation (ENI).<h4>Methods</h4>Using the National Cancer Database (NCDB), we identified patients with cT1-4N0M0 PDAC diagnosed between 2006 and 2020 treated with multiagent NAC, radiation with ENI, followed by curative resection with nodal dissection. A LASSO logistic regression model was used to predict ypN0 status, with generation of a nomogram and assessment of outcomes in training and testing cohorts. Secondary endpoints of negative-margin resection and overall2025-01-01T00:00:00Z2025 Dec2026-06-05T22:36:11.184Z2026-05-23T03:10:14.295ZS-EPMC126794864134766910.1002/cam4.71447