{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(12)"],"submitter":["Li Z"],"pubmed_abstract":["<h4>Background</h4>Melasma pathogenesis involves multifactorial mechanisms, and a comprehensive strategy achieves superior outcomes compared to monotherapy. Intense pulsed light (IPL) reduces pigmentation via selective photothermal effects, while microneedling enhances melanin clearance through mechanical stimulation and improves transdermal drug delivery. However, the therapeutic synergy of combining IPL with microneedling for melasma management requires further validation.<h4>Objective</h4>To assess the clinical effectiveness of combining IPL and microneedling with a postbiotic formulation containing Lactobacillus fermentation lysate in facial melasma.<h4>Methods</h4>Thirty individuals were enlisted and randomly split into two groups. IPL therapy group: Received IPL treatments at 4-week "],"journal":["Journal of cosmetic dermatology"],"pagination":["e70580"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12679679"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy of the Combination Therapy of Intense Pulsed Light and Microneedling With a Postbiotic Formulation for Melasma."],"pmcid":["PMC12679679"],"pubmed_authors":["Meng Q","Lei H","Huang G","Ma X","Wang H","Wang J","Wu H","Cong L","Ou M","Jiang X","Chen Y","Wu T","Zhou H","Yan L","Li C","Yang M","Xiao X","Zhu H","Li Z","Li T","Hu J","Zhang Y","Zhang X","Xiang Y","Meng J","Bi Y"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of the Combination Therapy of Intense Pulsed Light and Microneedling With a Postbiotic Formulation for Melasma.","description":"<h4>Background</h4>Melasma pathogenesis involves multifactorial mechanisms, and a comprehensive strategy achieves superior outcomes compared to monotherapy. Intense pulsed light (IPL) reduces pigmentation via selective photothermal effects, while microneedling enhances melanin clearance through mechanical stimulation and improves transdermal drug delivery. However, the therapeutic synergy of combining IPL with microneedling for melasma management requires further validation.<h4>Objective</h4>To assess the clinical effectiveness of combining IPL and microneedling with a postbiotic formulation containing Lactobacillus fermentation lysate in facial melasma.<h4>Methods</h4>Thirty individuals were enlisted and randomly split into two groups. IPL therapy group: Received IPL treatments at 4-week ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T22:34:43.507Z","creation":"2026-05-23T03:08:49.085Z"},"accession":"S-EPMC12679679","cross_references":{"pubmed":["41347603"],"doi":["10.1111/jocd.70580"]}}