{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(4)"],"submitter":["Head R"],"pubmed_abstract":["Drug repurposing is an authentic, emerging, and growing aspect of drug development when the demand for new therapeutic solutions is high. Many repurposed drugs have been discovered by serendipity or a non-ordered process driven by chance and sharp observation. These discoveries provide strong evidence for the existence of pharmacological pleiotropy, a highly ordered process well described by thermodynamics. Pleiotropy is an efficient way of propagating information and maintaining the specificity of a biological message and has been a cornerstone in genetics research over decades. While the definition, scale, diversity, and complexity associated with drug repurposing are well documented, pharmaceutical pleiotropy that is fundamental to our understanding of drug repurposing remains less expl"],"journal":["Pharmacology research & perspectives"],"pagination":["e70158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12679946"],"repository":["biostudies-literature"],"pubmed_title":["A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics."],"pmcid":["PMC12679946"],"pubmed_authors":["Islam S","Martin JH","Head R"],"additional_accession":[]},"is_claimable":false,"name":"A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics.","description":"Drug repurposing is an authentic, emerging, and growing aspect of drug development when the demand for new therapeutic solutions is high. Many repurposed drugs have been discovered by serendipity or a non-ordered process driven by chance and sharp observation. These discoveries provide strong evidence for the existence of pharmacological pleiotropy, a highly ordered process well described by thermodynamics. Pleiotropy is an efficient way of propagating information and maintaining the specificity of a biological message and has been a cornerstone in genetics research over decades. While the definition, scale, diversity, and complexity associated with drug repurposing are well documented, pharmaceutical pleiotropy that is fundamental to our understanding of drug repurposing remains less expl","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-08T04:57:57.412Z","creation":"2026-06-08T03:09:18.22Z"},"accession":"S-EPMC12679946","cross_references":{"pubmed":["40716111"],"doi":["10.1002/prp2.70158"]}}