biostudies-literatureUnknown7(6)Verhelst HHemispheric lateralization has been central to developmental dyslexia research for over a century, yet its role in the aetiology of reading and language deficits remains elusive. While altered asymmetries have long been implicated, evidence is inconsistent, with limited consideration given to individual variability in lateralization patterns. This study investigated hemispheric lateralization in 35 adults with dyslexia and 35 matched controls using functional MRI across three language tasks: word generation, rhyming decision and lexical decision. Laterality indices were calculated to comprehensively assess the strength, direction, and consistency of activation across global and regional task-specific brain areas. Significant group differences were not found in the absolute strength of lateBrain communicationsfcaf444https://www.ebi.ac.uk/biostudies/studies/S-EPMC12680132biostudies-literatureRevisiting atypical language lateralization in dyslexia.PMC12680132Gerrits RVingerhoets GKarlsson EMVerhelst HfalseRevisiting atypical language lateralization in dyslexia.Hemispheric lateralization has been central to developmental dyslexia research for over a century, yet its role in the aetiology of reading and language deficits remains elusive. While altered asymmetries have long been implicated, evidence is inconsistent, with limited consideration given to individual variability in lateralization patterns. This study investigated hemispheric lateralization in 35 adults with dyslexia and 35 matched controls using functional MRI across three language tasks: word generation, rhyming decision and lexical decision. Laterality indices were calculated to comprehensively assess the strength, direction, and consistency of activation across global and regional task-specific brain areas. Significant group differences were not found in the absolute strength of late2025-01-01T00:00:00Z20252026-06-05T23:24:37.161Z2026-05-23T03:13:07.413ZS-EPMC126801324135735010.1093/braincomms/fcaf444