{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shen W"],"funding":["Bill and Melinda Gates Foundation"],"pagination":["e70628"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12680929"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["124(5)"],"pubmed_abstract":["Geminiviruses are single-stranded DNA viruses that infect many plant species and cause serious losses in agronomically important crops. An earlier study showed that the Arabidopsis thaliana ecotype Pla-1 is resistant to infection by diverse geminivirus species and mapped the major resistance locus Geminivirus Resistance of Pla-1 1 (GRP1) to chromosome 1. In this study, we fine-mapped the GRP1 locus to a 0.6-Mb region and showed that its strength is gene-dosage-dependent. We also uncovered two minor resistance loci, GRP2 and GRP3, that mapped to chromosomes 3 and 5, respectively, and showed that GRP3 resistance is dependent on GRP1. RNA-Seq analysis of plants inoculated with the geminivirus, cabbage leaf curl virus (CaLCuV, Begomovirus brassicae), showed that AT1G31540, which is located in "],"journal":["The Plant journal : for cell and molecular biology"],"pubmed_title":["A TIR-NLR gene from Arabidopsis Pla-1 confers resistance to geminivirus infection."],"pmcid":["PMC12680929"],"funding_grant_id":["OPP1149990"],"pubmed_authors":["Wheeler E","Rajrani R","Ndunguru J","Deppong D","Hanley-Bowdoin L","Mickelson-Young L","Ascencio-Ibanez JT","Reyes MI","Shen W"],"additional_accession":[]},"is_claimable":false,"name":"A TIR-NLR gene from Arabidopsis Pla-1 confers resistance to geminivirus infection.","description":"Geminiviruses are single-stranded DNA viruses that infect many plant species and cause serious losses in agronomically important crops. An earlier study showed that the Arabidopsis thaliana ecotype Pla-1 is resistant to infection by diverse geminivirus species and mapped the major resistance locus Geminivirus Resistance of Pla-1 1 (GRP1) to chromosome 1. In this study, we fine-mapped the GRP1 locus to a 0.6-Mb region and showed that its strength is gene-dosage-dependent. We also uncovered two minor resistance loci, GRP2 and GRP3, that mapped to chromosomes 3 and 5, respectively, and showed that GRP3 resistance is dependent on GRP1. RNA-Seq analysis of plants inoculated with the geminivirus, cabbage leaf curl virus (CaLCuV, Begomovirus brassicae), showed that AT1G31540, which is located in ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T23:24:39.499Z","creation":"2026-05-23T03:13:07.881Z"},"accession":"S-EPMC12680929","cross_references":{"pubmed":["41351323"],"doi":["10.1111/tpj.70628"]}}