{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang Y"],"funding":["National Natural Science Foundation of China"],"pagination":["103934"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12681906"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88"],"pubmed_abstract":["Protein S-persulfidation, a post-translational modification mediated by hydrogen sulfide (H<sub>2</sub>S), plays an essential role in regulating protein function. However, current profiling methods, mainly based on liquid chromatography-tandem mass spectrometry (LC-MS/MS), tend to detect abundant proteins and often miss low-abundance but important regulators like transcription factors (TFs). To better understand the S-persulfidation landscape, we integrated datasets from three species-Homo sapiens, Mus musculus, and Arabidopsis thaliana-and found that TFs are strikingly underrepresented. To address this gap, we applied oxidative proteomics data from the Oximouse database, which reflects age-related redox changes, and identified hepatocyte nuclear factor 1α (HNF1α) as a candidate S-persulfi"],"journal":["Redox biology"],"pubmed_title":["Functional S-persulfidation exploration reveals a novel regulatory mechanism of HNF1α."],"pmcid":["PMC12681906"],"funding_grant_id":["T24B2015","81921001","81670395"],"pubmed_authors":["Chen N","Yang J","Li J","Wang C","Zhang H","Bu D","Tang C","Zhang L","Wang J","Cui Q","Wang L","Li W","Peng H","Li Z","Geng B","Jin H","Huang Y","Wang S","Du J","Wang Y","Chen S","Cui C","Chu M"],"additional_accession":[]},"is_claimable":false,"name":"Functional S-persulfidation exploration reveals a novel regulatory mechanism of HNF1α.","description":"Protein S-persulfidation, a post-translational modification mediated by hydrogen sulfide (H<sub>2</sub>S), plays an essential role in regulating protein function. However, current profiling methods, mainly based on liquid chromatography-tandem mass spectrometry (LC-MS/MS), tend to detect abundant proteins and often miss low-abundance but important regulators like transcription factors (TFs). To better understand the S-persulfidation landscape, we integrated datasets from three species-Homo sapiens, Mus musculus, and Arabidopsis thaliana-and found that TFs are strikingly underrepresented. To address this gap, we applied oxidative proteomics data from the Oximouse database, which reflects age-related redox changes, and identified hepatocyte nuclear factor 1α (HNF1α) as a candidate S-persulfi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T23:38:08.243Z","creation":"2026-05-23T03:13:54.831Z"},"accession":"S-EPMC12681906","cross_references":{"pubmed":["41274036"],"doi":["10.1016/j.redox.2025.103934"]}}