{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hsi-Bell J"],"funding":["National Institute of Nursing Research","National Institute of General Medical Sciences","National Science Foundation"],"pagination":["101629"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12682079"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(4)"],"pubmed_abstract":["Over the past ∼25 years, structural studies of adeno-associated virus (AAV) capsids have greatly aided our understanding of the biology of these single-stranded DNA viruses and provided insights into their utilization as gene therapy vectors for the treatment of various human diseases. Recent advances in cryo-electron microscopy have yielded a library of currently ∼150 high-resolution AAV capsid structures, with more than 50% determined in the last 5 years alone. Comparative analyses of capsids from primate and nonprimate origins have revealed both conserved architectural elements, such as the canonical jelly-roll fold, and critical surface variations that affect receptor interaction, antibody recognition, and intracellular trafficking. These structures, as well as those in complex with gl"],"journal":["Molecular therapy. Methods & clinical development"],"pubmed_title":["The amazing AAV capsids: Into the structure-verse."],"pmcid":["PMC12682079"],"funding_grant_id":["GM082946","DGE-2236414"],"pubmed_authors":["Mietzsch M","Hsi-Bell J","McKenna R"],"additional_accession":[]},"is_claimable":false,"name":"The amazing AAV capsids: Into the structure-verse.","description":"Over the past ∼25 years, structural studies of adeno-associated virus (AAV) capsids have greatly aided our understanding of the biology of these single-stranded DNA viruses and provided insights into their utilization as gene therapy vectors for the treatment of various human diseases. Recent advances in cryo-electron microscopy have yielded a library of currently ∼150 high-resolution AAV capsid structures, with more than 50% determined in the last 5 years alone. Comparative analyses of capsids from primate and nonprimate origins have revealed both conserved architectural elements, such as the canonical jelly-roll fold, and critical surface variations that affect receptor interaction, antibody recognition, and intracellular trafficking. These structures, as well as those in complex with gl","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T00:29:53.925Z","creation":"2026-05-24T03:11:40.681Z"},"accession":"S-EPMC12682079","cross_references":{"pubmed":["41362290"],"doi":["10.1016/j.omtm.2025.101629"]}}