{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nagarajan P"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","NHGRI NIH HHS","U.S. Department of Veterans Affairs (Department of Veterans Affairs)","U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)","CSRD VA"],"pagination":["3660-3672"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12683674"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(8)"],"pubmed_abstract":["Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discovered 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-over"],"journal":["Molecular psychiatry"],"pubmed_title":["A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations."],"pmcid":["PMC12683674"],"funding_grant_id":["R01 HL163262","K26 DK138425","R01 HL156991","R01 HL163972","R01HL156991","R01 HL118305","I01 CX001897","CX001897","R01HL118305","R01 HG013163"],"pubmed_authors":["Iruvanti P","Psaty BM","Kawaguchi T","Gappy S","Luan J","Menni C","Stadler S","Matsuda F","Jhala D","Faquih T","Gutierrez S","Riha RL","Westerman KE","Pacheco NL","Aguayo S","Holliday EG","Poon S","Nolte IM","He J","DuVall SL","Raitakari OT","Brewer JV","Okusaga O","Below JE","Morrison JL","Do A","Bartz TM","Edwards TL","Xu J","Lyytikainen LP","Scott RJ","Levy D","Churby L","Boger CA","Heid IM","Hung AM","Nagarajan P","Potter E","Whooley M","Zhao W","Harley J","Liangpunsakul S","Hanley AJ","Munroe PB","Wagenknecht LE","Brown MR","de Las Fuentes L","Bazzanno L","Gupta S","Faulk LC","Volker U","Kho M","Milaneschi Y","Aschard H","Vollenweider P","Mahan CS","Fox ER","Zhu X","Zhu W","Cohen D","Lo TS","Matheny M","Rotter JI","Dryden GW","Rao V","Theriault S","Rich SS","Argoty-Pantoja AD","Wells J","Chen Z","Million Veteran Program","Marques-Vidal P","Villareal G","Li C","Magi R","Tsao PS","Sharma S","Bast ES","Kahonen M","Franceschini N","Xia R","Chen H","Meyer P","Altschul D","Lawlor DA","Liu CT","Gesek F","Assimes TL","Kelly TN","Du J","Lin HJ","Fornage M","Landry M","Feitosa MF","Whittle J","Winkler TW","Muralidhar S","Pyarajan S","Sitlani CM","Mangino M","Selva LE","Weiss S","Fayad J","Nam K","Kazuya S","Harlow SD","Dupont CT","Petty LE","Walsh J","Snieder H","Dimitrov LM","Rauchman M","Mattocks K","Bhushan S","Gaziano JM","Marrache R","Wilson P","Province MA","Lefevre C","Guo X","McCormick JB","Conen D","Chen HH","Gudnason V","Attia JR","Shen B","Whitbourne SB","Morrison AC","Zhang R","Petrakis I","Highland HM","Hairston KG","Harris SE","Gress TW","Wilson OD","Karvonen-Gutierrez CA","Argyres DP","Connor T","Liu PY","Kinlay S","Liang P","O'Connell JR","Miller CL","Risch M","Floyd JS","Felix SB","Norton J","Risch L","Godschalk M","Moser J","Ansari MAY","Dellitalia L","Gharib SA","Redline S","Gudmundsdottir V","Cox SR","Hauser E","Kranzler H","Schwander K","Ahuja S","Noordam R","Rauramaa R","Shayan SA","Ballas Z","Moorman J","Lee S","Kraja AT","Meigs JB","Gauderman J","Graff M","Lichy J","Hogan DJ","Androulakis XM","Tang J","Deen JE","Kilbourne A","Tandon N","Wareham NJ","Smith JA","Servatius R","Penninx BW","Fisher-Hoch SP","Balasubramanian P","Rai AS","Sriram P","Palmer ND","Hood MM","Greco J","Murdoch M","Huang Z","Komulainen P","Ong MK","Polikowsky HG","Lakka TA","de Vries PS","Manning AK","Willems van Dijk K","Young KL","Wang G","Wang H","Stephens B","Gu D","Zonderman AB","Beckham J","Gu C","Sun Q","Boyko E","Ruiz-Narvaez EA","Spector TD","Wang W","Wang Y","Morales P","Oslin D","Yao J","Raffield LM","Mastorides S","Brophy MT","Anugu P","Heikkinen S","Evans MK","van der Graaf A","Brody JA","Naik E","Peyser PA","Jacono F","Hurley R","Yang Q","Fujii D","Breyer MA","Giri A","Dorr M","Kutalik Z","van der Most PJ","Teder-Laving M","Hung A","Alexander K","Bentley AR","Arzt M","Cho K","Sofer T","Yeh SS","Hamner M","Yasuharu T","Lehtimaki T","Rao DC","Strollo P","Kals M","Cade BE","Mei H","Yen AW","Oursler KA","Smith R","Morgan T","van Heemst D","Chen YI","North KE"],"additional_accession":[]},"is_claimable":false,"name":"A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.","description":"Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discovered 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-over","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-07T04:58:29.895Z","creation":"2026-06-07T03:07:31.598Z"},"accession":"S-EPMC12683674","cross_references":{"pubmed":["40181193"],"doi":["10.1038/s41380-025-02954-w"]}}