biostudies-literatureUnknown23(1)Kanehira N<h4>Background</h4>Boron neutron capture therapy (BNCT) is a molecularly targeted chemoradiation modality that relies on boron delivery agents such as p-borophenylalanine (BPA), which require LAT1 (L-type amino acid transporter 1) for tumor uptake. However, the limited efficacy of BPA in LAT1-low tumors restricts its therapeutic scope. To address this limitation, we developed a tumor marker-guided BNCT strategy targeting cancers overexpressing the clinically validated glycan biomarker CA19-9.<h4>Methods</h4>We conducted transcriptomic analyses using The Cancer Genome Atlas (TCGA) datasets to identify LAT1-low cancers with high CA19-9 expression. These analyses revealed elevated expression of fucosyltransferase 3 (FUT3), which underlies CA19-9 biosynthesis, in pancreatic, biliary, and ovariJournal of translational medicine1387https://www.ebi.ac.uk/biostudies/studies/S-EPMC12683832biostudies-literatureTumor marker-guided precision BNCT for CA19-9-positive cancers: a new paradigm in molecularly targeted chemoradiation therapy.PMC12683832Shigeyasu KSuzuki MFujita TFujimoto TGotoh KSakurai YTakarada TKamei KTajima TOsone TMichiue HNagahisa NKanehira NFujiwara TKondo NMorihara ATakaguchi YTeraishi FKitamatsu MfalseTumor marker-guided precision BNCT for CA19-9-positive cancers: a new paradigm in molecularly targeted chemoradiation therapy.<h4>Background</h4>Boron neutron capture therapy (BNCT) is a molecularly targeted chemoradiation modality that relies on boron delivery agents such as p-borophenylalanine (BPA), which require LAT1 (L-type amino acid transporter 1) for tumor uptake. However, the limited efficacy of BPA in LAT1-low tumors restricts its therapeutic scope. To address this limitation, we developed a tumor marker-guided BNCT strategy targeting cancers overexpressing the clinically validated glycan biomarker CA19-9.<h4>Methods</h4>We conducted transcriptomic analyses using The Cancer Genome Atlas (TCGA) datasets to identify LAT1-low cancers with high CA19-9 expression. These analyses revealed elevated expression of fucosyltransferase 3 (FUT3), which underlies CA19-9 biosynthesis, in pancreatic, biliary, and ovari2025-01-01T00:00:00Z2025 Dec2026-06-07T03:13:46.642Z2026-06-07T03:07:13.341ZS-EPMC126838324136182310.1186/s12967-025-07349-7