{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Calderon RI"],"funding":["NICHD NIH HHS","NCATS NIH HHS","HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","HHS | NIH","California Institute for Regenerative Medicine","California Institute for Regenerative Medicine (CIRM)","Wellcome Trust","HHS | NIH (NIH)","NIGMS NIH HHS","NIH HHS"],"pagination":["e2508432122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12685074"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(48)"],"pubmed_abstract":["The trophectoderm (TE), the first lineage specified during mammalian development, initiates implantation and gives rise to placental trophoblasts. While animal models have elucidated key conserved signaling pathways involved in early TE specification, including bone morphogenetic protein (BMP), WNT, and HIPPO, species-specific differences during early development emphasize the need for human-specific models. We previously identified VGLL1, a coactivator of TEAD transcription factors, as a human-specific placental marker. In this study, we employed a pluripotent stem cell (PSC)-based model of TE induction by BMP4 to investigate chromatin remodeling and transcriptional dynamics during TE formation. BMP4-induced chromatin accessibility changes promoted a trophoblast gene expression program, w"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment."],"pmcid":["PMC12685074"],"funding_grant_id":["R01 HD113673","UL1TR001442","HD103161","R35 GM157073","DISC0-13816","UL1 TR001442","CC2074","R01 HD101319","DISC0-13757","GM145427","R01 HD062546","R01 HD096260","R01HD096260","HD119510","HD101319","HD062546","R21 HD119510","EDUC4-12804","221856/Z/20/Z","S10 OD026929","R01 HD103161","T32 GM145427","HD113673"],"pubmed_authors":["Gerri C","De Hoff P","Kallol S","Home P","Huang M","Mitre A","Morey R","Paul S","Abdelbaki A","Fisch KM","Manalo Z","Kittle RH","Bui T","Soncin F","Shaik WB","Chousal JN","Fogarty NME","Sah N","Zheng C","Calderon RI","Cook-Andersen H","Niakan KK"],"additional_accession":[]},"is_claimable":false,"name":"VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment.","description":"The trophectoderm (TE), the first lineage specified during mammalian development, initiates implantation and gives rise to placental trophoblasts. While animal models have elucidated key conserved signaling pathways involved in early TE specification, including bone morphogenetic protein (BMP), WNT, and HIPPO, species-specific differences during early development emphasize the need for human-specific models. We previously identified VGLL1, a coactivator of TEAD transcription factors, as a human-specific placental marker. In this study, we employed a pluripotent stem cell (PSC)-based model of TE induction by BMP4 to investigate chromatin remodeling and transcriptional dynamics during TE formation. BMP4-induced chromatin accessibility changes promoted a trophoblast gene expression program, w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T00:27:09.487Z","creation":"2026-05-24T03:11:15.698Z"},"accession":"S-EPMC12685074","cross_references":{"pubmed":["41284866"],"doi":["10.1073/pnas.2508432122"]}}