biostudies-literatureUnknown17(1)Nakao J<h4>Introduction</h4>Heat stroke is a life-threatening condition characterized by hyperthermia and central nervous system (CNS) dysfunction, and often leads to multiorgan damage. Both intestinal and neurological complications have been individually reported in severe cases of exertional heat stroke (EHS); however, their concurrent presentation is rare.<h4>Case presentation</h4>We hereby report the case of a 48-year-old man with a history of untreated hypertension, who collapsed when working outdoors in hot and humid weather. He was brought in a comatose condition with hypotension and a core body temperature of 40.6°C. Initial whole-body computed tomography (CT) revealed intestinal edema. Brain CT indicated no abnormalities; however, magnetic resonance imaging (MRI) on Day 3 revealed diffusCase reports in neurology184-190https://www.ebi.ac.uk/biostudies/studies/S-EPMC12685346biostudies-literatureSevere Exertional Heat Stroke with Intestinal Edema and Concurrent Hippocampal Abnormal Signals and Lacunar Infarction: A Case Report.PMC12685346Yamakawa KAmemiya YTanaka SWanibuchi MTakasu AHiramatsu RHatakeyama JNakao JfalseSevere Exertional Heat Stroke with Intestinal Edema and Concurrent Hippocampal Abnormal Signals and Lacunar Infarction: A Case Report.<h4>Introduction</h4>Heat stroke is a life-threatening condition characterized by hyperthermia and central nervous system (CNS) dysfunction, and often leads to multiorgan damage. Both intestinal and neurological complications have been individually reported in severe cases of exertional heat stroke (EHS); however, their concurrent presentation is rare.<h4>Case presentation</h4>We hereby report the case of a 48-year-old man with a history of untreated hypertension, who collapsed when working outdoors in hot and humid weather. He was brought in a comatose condition with hypotension and a core body temperature of 40.6°C. Initial whole-body computed tomography (CT) revealed intestinal edema. Brain CT indicated no abnormalities; however, magnetic resonance imaging (MRI) on Day 3 revealed diffus2025-01-01T00:00:00Z2025 Jan-Dec2026-06-07T04:50:24.996Z2026-06-07T03:06:59.677ZS-EPMC126853464136861010.1159/000549492