biostudies-literatureUnknown116(1)Gutierrez-Guerra MAUniversidad de ExtremaduraStudies evaluating habitual dietary copper intake and bone mineral density have garnered significant interest due to copper's indispensable role in collagen cross-linking and osteogenesis. These investigations, which employ dietary assessment tools alongside DXA measurements of skeletal sites, have nonetheless yielded heterogeneous results regarding the impact of copper consumption on bone health. Consequently, elucidating the nature and magnitude of this association is of paramount importance for both nutritional epidemiology and osteoporosis prevention. The review was conducted in accordance with PRISMA guidelines and registered in Prospero (CRD42024617075). Electronic literature searches were performed up to February 2025 in EMBASE, PubMed, OVID, Scopus, and Web of Science to identify oCalcified tissue international149https://www.ebi.ac.uk/biostudies/studies/S-EPMC12686089biostudies-literatureDietary Copper Intake and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies.PMC12686089Vera VLavado-Garcia JMMoran JMPastor-Ramon ELopez-Espuela FPedrera-Zamorano JDPuerto-Parejo LMGutierrez-Guerra MAPedrera-Canal MFabregat-Fernandez JRoncero-Martin RfalseDietary Copper Intake and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies.Studies evaluating habitual dietary copper intake and bone mineral density have garnered significant interest due to copper's indispensable role in collagen cross-linking and osteogenesis. These investigations, which employ dietary assessment tools alongside DXA measurements of skeletal sites, have nonetheless yielded heterogeneous results regarding the impact of copper consumption on bone health. Consequently, elucidating the nature and magnitude of this association is of paramount importance for both nutritional epidemiology and osteoporosis prevention. The review was conducted in accordance with PRISMA guidelines and registered in Prospero (CRD42024617075). Electronic literature searches were performed up to February 2025 in EMBASE, PubMed, OVID, Scopus, and Web of Science to identify o2025-01-01T00:00:00Z2025 Dec2026-06-06T20:04:19.941Z2026-06-04T03:14:57.542ZS-EPMC126860894136165510.1007/s00223-025-01463-w