biostudies-literatureUnknown41(1)Saad NMansoura University<h4>Background</h4>Nephrotic syndrome (NS) is a common pediatric kidney disorder characterized by proteinuria, hypoalbuminemia, and edema. Leukotrienes (LTs), as inflammatory mediators, may contribute to NS pathogenesis and influence treatment response. This study aimed to assess urinary leukotriene E4 (LTE4) levels in children with an initial onset of NS and evaluate their potential as biomarkers for steroid responsiveness.<h4>Methods</h4>In this observational cohort study, 41 children with a first episode of NS and 41 age- and sex-matched healthy controls were enrolled. Patients were classified into steroid-sensitive NS (SSNS; n = 29) and steroid-resistant NS (SRNS; n = 12) groups following initial steroid therapy. Urinary LTE4 levels were measured prior to treatment, using enzyme-linkedPediatric nephrology (Berlin, Germany)101-108https://www.ebi.ac.uk/biostudies/studies/S-EPMC12686090biostudies-literatureUrinary leukotriene E4 for predicting steroid sensitivity in children with nephrotic syndrome: an observational cohort study.PMC12686090Osman AMansour MSaad NBakr AMfalseUrinary leukotriene E4 for predicting steroid sensitivity in children with nephrotic syndrome: an observational cohort study.<h4>Background</h4>Nephrotic syndrome (NS) is a common pediatric kidney disorder characterized by proteinuria, hypoalbuminemia, and edema. Leukotrienes (LTs), as inflammatory mediators, may contribute to NS pathogenesis and influence treatment response. This study aimed to assess urinary leukotriene E4 (LTE4) levels in children with an initial onset of NS and evaluate their potential as biomarkers for steroid responsiveness.<h4>Methods</h4>In this observational cohort study, 41 children with a first episode of NS and 41 age- and sex-matched healthy controls were enrolled. Patients were classified into steroid-sensitive NS (SSNS; n = 29) and steroid-resistant NS (SRNS; n = 12) groups following initial steroid therapy. Urinary LTE4 levels were measured prior to treatment, using enzyme-linked2026-01-01T00:00:00Z2026 Dec2026-05-26T17:03:37.405Z2026-05-24T03:11:36.377ZS-EPMC126860904102849710.1007/s00467-025-06952-6