{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dou Q"],"funding":["National Natural Science Foundation of China"],"pagination":["439"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12686328"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["82(1)"],"pubmed_abstract":["Sepsis-associated acute kidney injury (SAKI) is a severe condition associated with high mortality and long-term complications. Currently, there is no effective strategy to halt AKI chronicization. Stress-induced senescence of renal tubular epithelial cells (RTECs) is a pivotal driving mechanism in the AKI-CKD transition. Previous scRNA-seq revealed that the expression of immediate early response gene 3 (IER3) was markedly upregulated in the senescent RTECs of patients with AKI and that the IER3<sup>+</sup>RTEC subpopulation exhibited diminished differentiation potential and impaired self-renewal capacity. However, the role of IER3 in RTEC stress-induced senescence following AKI remains unclear. In this study, we found that knockout of IER3 reduced mortality rates, alleviated renal injury, "],"journal":["Cellular and molecular life sciences : CMLS"],"pubmed_title":["IER3 drives the transition from sepsis-associated AKI to CKD by suppressing the mitochondrial translocation of PRDX5."],"pmcid":["PMC12686328"],"funding_grant_id":["82400847","82270768, 8240035944"],"pubmed_authors":["Yi X","Chen K","Chen J","He J","Dou Q","Bai L","Tong H"],"additional_accession":[]},"is_claimable":false,"name":"IER3 drives the transition from sepsis-associated AKI to CKD by suppressing the mitochondrial translocation of PRDX5.","description":"Sepsis-associated acute kidney injury (SAKI) is a severe condition associated with high mortality and long-term complications. Currently, there is no effective strategy to halt AKI chronicization. Stress-induced senescence of renal tubular epithelial cells (RTECs) is a pivotal driving mechanism in the AKI-CKD transition. Previous scRNA-seq revealed that the expression of immediate early response gene 3 (IER3) was markedly upregulated in the senescent RTECs of patients with AKI and that the IER3<sup>+</sup>RTEC subpopulation exhibited diminished differentiation potential and impaired self-renewal capacity. However, the role of IER3 in RTEC stress-induced senescence following AKI remains unclear. In this study, we found that knockout of IER3 reduced mortality rates, alleviated renal injury, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T23:42:58.697Z","creation":"2026-05-23T03:13:32.087Z"},"accession":"S-EPMC12686328","cross_references":{"pubmed":["41359162"],"doi":["10.1007/s00018-025-05963-8"]}}