{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yokosawa R"],"funding":["JST SPRING","Daiko Foundation","JST","Japan Science and Technology Agency","JSPS","Japan Society for the Promotion of Science"],"pagination":["e70277"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12686552"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(12)"],"pubmed_abstract":["A decline in food-searching behavior of post-reproductive animals can benefit the population and possibly be programmed by the genome despite its detrimental effect on an individual. We investigated the genetic program of age-dependent decline in chemotaxis behavior toward an odorant secreted from bacterial food in C. elegans. Through a novel forward genetic screen, we identified the gene encoding a nuclear hormone receptor, nhr-76, whose mutants ameliorate the age-dependent chemotaxis decline. We found that NHR-76 downregulates odorant receptor expression during aging in a ligand-binding-domain-dependent manner. Since NHR-76 expression and localization remain unchanged with age, its activity may be modulated through the ligand-binding domain, leading to age-dependent chemotaxis decline. Our findings imply that post-reproductive behavioral decline can be genetically programmed."],"journal":["Aging cell"],"pubmed_title":["A Nuclear Hormone Receptor nhr-76 Induces Age-Dependent Chemotaxis Decline in C. elegans."],"pmcid":["PMC12686552"],"funding_grant_id":["JPMJSP2125","JPMJFR 214V","No.9286","JP 21K06014"],"pubmed_authors":["Yokosawa R","Noma K"],"additional_accession":[]},"is_claimable":false,"name":"A Nuclear Hormone Receptor nhr-76 Induces Age-Dependent Chemotaxis Decline in C. elegans.","description":"A decline in food-searching behavior of post-reproductive animals can benefit the population and possibly be programmed by the genome despite its detrimental effect on an individual. We investigated the genetic program of age-dependent decline in chemotaxis behavior toward an odorant secreted from bacterial food in C. elegans. Through a novel forward genetic screen, we identified the gene encoding a nuclear hormone receptor, nhr-76, whose mutants ameliorate the age-dependent chemotaxis decline. We found that NHR-76 downregulates odorant receptor expression during aging in a ligand-binding-domain-dependent manner. Since NHR-76 expression and localization remain unchanged with age, its activity may be modulated through the ligand-binding domain, leading to age-dependent chemotaxis decline. Our findings imply that post-reproductive behavioral decline can be genetically programmed.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-23T03:25:51.841Z","creation":"2026-05-23T03:13:50.896Z"},"accession":"S-EPMC12686552","cross_references":{"pubmed":["41128441"],"doi":["10.1111/acel.70277"]}}