{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["57"],"submitter":["Xie S"],"pubmed_abstract":["<h4>Objective</h4>Current bone adhesives typically lack adequate mechanical strength, long-term stability, or biocompatibility. To address these limitations, we designed a new adhesion strategy using a solid-state hydroxyapatite (HAp) adhesive in combination with bone surface demineralization.<h4>Methods</h4>Solid-state HAp adhesives were synthesized via wet chemical precipitation and heat treatment. Cortical bone specimens were partially demineralized with phosphoric acid (H<sub>3</sub>PO<sub>4</sub>) or ethylenediaminetetraacetic acid (EDTA), and characterized using scanning electron microscopy (SEM) and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). Shear adhesion strength of HAp to demineralized bone was measured over time. <i>In vivo</i> fixation was "],"journal":["Bioactive materials"],"pagination":["632-645"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12686729"],"repository":["biostudies-literature"],"pubmed_title":["Robust adhesion between solid-state hydroxyapatite and bone tissue through surface demineralization."],"pmcid":["PMC12686729"],"pubmed_authors":["Yang X","Aoyagi H","Matsumoto T","Otaka A","Okada M","Nakano T","Xie S"],"additional_accession":[]},"is_claimable":false,"name":"Robust adhesion between solid-state hydroxyapatite and bone tissue through surface demineralization.","description":"<h4>Objective</h4>Current bone adhesives typically lack adequate mechanical strength, long-term stability, or biocompatibility. To address these limitations, we designed a new adhesion strategy using a solid-state hydroxyapatite (HAp) adhesive in combination with bone surface demineralization.<h4>Methods</h4>Solid-state HAp adhesives were synthesized via wet chemical precipitation and heat treatment. Cortical bone specimens were partially demineralized with phosphoric acid (H<sub>3</sub>PO<sub>4</sub>) or ethylenediaminetetraacetic acid (EDTA), and characterized using scanning electron microscopy (SEM) and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). Shear adhesion strength of HAp to demineralized bone was measured over time. <i>In vivo</i> fixation was ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-06-06T00:31:20.105Z","creation":"2026-05-24T03:11:52.666Z"},"accession":"S-EPMC12686729","cross_references":{"pubmed":["41377895"],"doi":["10.1016/j.bioactmat.2025.11.030"]}}