biostudies-literatureUnknown57Xie S<h4>Objective</h4>Current bone adhesives typically lack adequate mechanical strength, long-term stability, or biocompatibility. To address these limitations, we designed a new adhesion strategy using a solid-state hydroxyapatite (HAp) adhesive in combination with bone surface demineralization.<h4>Methods</h4>Solid-state HAp adhesives were synthesized via wet chemical precipitation and heat treatment. Cortical bone specimens were partially demineralized with phosphoric acid (H₃PO₄) or ethylenediaminetetraacetic acid (EDTA), and characterized using scanning electron microscopy (SEM) and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). Shear adhesion strength of HAp to demineralized bone was measured over time. <i>In vivo</i> fixation was Bioactive materials632-645https://www.ebi.ac.uk/biostudies/studies/S-EPMC12686729biostudies-literatureRobust adhesion between solid-state hydroxyapatite and bone tissue through surface demineralization.PMC12686729Yang XAoyagi HMatsumoto TOtaka AOkada MNakano TXie SfalseRobust adhesion between solid-state hydroxyapatite and bone tissue through surface demineralization.<h4>Objective</h4>Current bone adhesives typically lack adequate mechanical strength, long-term stability, or biocompatibility. To address these limitations, we designed a new adhesion strategy using a solid-state hydroxyapatite (HAp) adhesive in combination with bone surface demineralization.<h4>Methods</h4>Solid-state HAp adhesives were synthesized via wet chemical precipitation and heat treatment. Cortical bone specimens were partially demineralized with phosphoric acid (H₃PO₄) or ethylenediaminetetraacetic acid (EDTA), and characterized using scanning electron microscopy (SEM) and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). Shear adhesion strength of HAp to demineralized bone was measured over time. <i>In vivo</i> fixation was 2026-01-01T00:00:00Z2026 Mar2026-06-06T00:31:20.105Z2026-05-24T03:11:52.666ZS-EPMC126867294137789510.1016/j.bioactmat.2025.11.030