{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(12)"],"submitter":["Chen X"],"pubmed_abstract":["Nasopharyngeal carcinoma (NPC) represents a malignant tumor linked to Epstein-Barr virus (EBV) that is characterized by distinctive, clinically relevant biological features. As protein N-glycosylation plays critical roles in cancer progression, we applied quantitative glycoproteomics to characterize NPC-specific glycosylation patterns. Using label-free proteomics and intact N-glycoproteomics, we analyzed 17 NPC tissues and 7 normal mucosal epithelia. Integrated analysis with PET/CT imaging and bioinformatics revealed correlations among differentially expressed glycoproteins, glycosyltransferases, and immunophenotypes. Functional validation demonstrated that MANEA, an enzyme linked to high-mannose glycosylation, influences NPC cell proliferation and migration. Furthermore, MANEA likely modu"],"journal":["Journal of proteome research"],"pagination":["6272-6284"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12687360"],"repository":["biostudies-literature"],"pubmed_title":["Proteomics Combined with N-Glycoproteomics to Explore the Pathogenesis of Nasopharyngeal Carcinoma."],"pmcid":["PMC12687360"],"pubmed_authors":["Lin Q","Li Z","Ling H","Chen X","Zhou Y","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Proteomics Combined with N-Glycoproteomics to Explore the Pathogenesis of Nasopharyngeal Carcinoma.","description":"Nasopharyngeal carcinoma (NPC) represents a malignant tumor linked to Epstein-Barr virus (EBV) that is characterized by distinctive, clinically relevant biological features. As protein N-glycosylation plays critical roles in cancer progression, we applied quantitative glycoproteomics to characterize NPC-specific glycosylation patterns. Using label-free proteomics and intact N-glycoproteomics, we analyzed 17 NPC tissues and 7 normal mucosal epithelia. Integrated analysis with PET/CT imaging and bioinformatics revealed correlations among differentially expressed glycoproteins, glycosyltransferases, and immunophenotypes. Functional validation demonstrated that MANEA, an enzyme linked to high-mannose glycosylation, influences NPC cell proliferation and migration. Furthermore, MANEA likely modu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T23:43:20.676Z","creation":"2026-05-23T03:13:36.987Z"},"accession":"S-EPMC12687360","cross_references":{"pubmed":["41269767"],"doi":["10.1021/acs.jproteome.5c00793"]}}