{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Bock SL"],"funding":["U.S. National Science Foundation","NIA NIH HHS","National Institute on Aging"],"pubmed_abstract":["Sexes frequently differ in life history traits including body size, lifespan, and age at sexual maturity. Aging, the progressive decline in physiological function and cellular resilience over time, is a central process contributing to sex-specific life histories, yet the mechanisms driving sex differences in aging remain largely unresolved. Long-term mark-recapture efforts revealed a striking pattern of female-biased longevity in the painted turtle (<i>Chrysemys picta</i>), a species with temperature-dependent sex determination. As a result, this species provides a compelling system to examine the mechanisms of sex-specific aging in the absence of sex chromosomes. Here, we characterize sex- and age-associated patterns in the blood transcriptomes of wild painted turtles (n = 93). We identif"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.11.26.690843"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12687789"],"repository":["biostudies-literature"],"pubmed_title":["Widespread sex-biased gene expression reflects female-biased longevity in a species with environmental sex determination."],"pmcid":["PMC12687789"],"funding_grant_id":["IOS-1257857","R01AG049416","R01 AG049416","DBI-2213824"],"pubmed_authors":["Adorsoo M","Janzen FJ","Hoekstra LA","Bronikowski AM","Hagerty K","Schmidt RE","Singh R","Bock SL","Judson J"],"additional_accession":[]},"is_claimable":false,"name":"Widespread sex-biased gene expression reflects female-biased longevity in a species with environmental sex determination.","description":"Sexes frequently differ in life history traits including body size, lifespan, and age at sexual maturity. Aging, the progressive decline in physiological function and cellular resilience over time, is a central process contributing to sex-specific life histories, yet the mechanisms driving sex differences in aging remain largely unresolved. Long-term mark-recapture efforts revealed a striking pattern of female-biased longevity in the painted turtle (<i>Chrysemys picta</i>), a species with temperature-dependent sex determination. As a result, this species provides a compelling system to examine the mechanisms of sex-specific aging in the absence of sex chromosomes. Here, we characterize sex- and age-associated patterns in the blood transcriptomes of wild painted turtles (n = 93). We identif","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-03T03:16:33.218Z","creation":"2026-06-03T03:10:48.122Z"},"accession":"S-EPMC12687789","cross_references":{"pubmed":["41377510"],"doi":["10.1101/2025.11.26.690843"]}}