biostudies-literatureFei XNational Natural Science Foundation of Chinae0150025https://www.ebi.ac.uk/biostudies/studies/S-EPMC12688083biostudies-literatureUnknown13(10)As an alternative to the tuberculin skin test (TST) or QuantiFERON-TB Gold In-Tube (QFT-GIT), ESAT6-CFP10 (EC) skin test is an emerging screening method; however, its value in the diagnosis of latent tuberculosis infection (LTBI) in detainees is still unclear in China. Newly admitted detainees meeting inclusion criteria were enrolled, with demographic/clinical data collected via structured questionnaires. TST, EC skin test, and QFT-GIT screenings were performed, documenting the diameter of skin indurations and/or redness at injection sites and blistering reactions at injection sites. In total, 1,038 detainees were enrolled in this study from October 2022 to October 2023 with 236 LTBI (22.7%). The positive rate of TST, EC skin test, and QFT-GIT was 18.1%, 10.6% and 11.9%. The area under theMicrobiology spectrumDiagnostic accuracy of the ESAT6-CFP10 skin test for latent tuberculosis infection among jail detainees.PMC1268808382574172, 82003516Martinez LWang SZhu LHu XTang PLiu QFei XChen CWang ZfalseDiagnostic accuracy of the ESAT6-CFP10 skin test for latent tuberculosis infection among jail detainees.As an alternative to the tuberculin skin test (TST) or QuantiFERON-TB Gold In-Tube (QFT-GIT), ESAT6-CFP10 (EC) skin test is an emerging screening method; however, its value in the diagnosis of latent tuberculosis infection (LTBI) in detainees is still unclear in China. Newly admitted detainees meeting inclusion criteria were enrolled, with demographic/clinical data collected via structured questionnaires. TST, EC skin test, and QFT-GIT screenings were performed, documenting the diameter of skin indurations and/or redness at injection sites and blistering reactions at injection sites. In total, 1,038 detainees were enrolled in this study from October 2022 to October 2023 with 236 LTBI (22.7%). The positive rate of TST, EC skin test, and QFT-GIT was 18.1%, 10.6% and 11.9%. The area under the2025-01-01T00:00:00Z2025 Oct2026-06-05T23:45:14.963Z2026-05-23T03:13:42.124ZS-EPMC126880834096028210.1128/spectrum.01500-25