{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(12)"],"submitter":["Ghafoor MS"],"pubmed_abstract":["Nucleoredoxin 1 (NRX1), a member of the redoxin superfamily, plays a critical role in maintaining redox homeostasis and enhancing stress tolerance in plants. We employed integrated in silico analyses and CRISPR-Cas9-based genome editing to functionally characterize NRX1 in <i>Triticum aestivum</i> (wheat) responding to salinity and infection by <i>Puccinia striiformis</i>. We identified five NRX1 proteins coded by three homeologs, with each containing conserved thioredoxin-like domains and a Cys-rich C-terminal region. Sequence analysis predicted cytosolic and chloroplast localization, and promoter analysis predicted interaction with numerous <i>cis</i>-regulatory elements responsive to stress and hormones, including ABRE, MeJARE, and LTRE motifs. Expression profiling revealed significant "],"journal":["Plant direct"],"pagination":["e70130"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12688404"],"repository":["biostudies-literature"],"pubmed_title":["Nucleoredoxin 1 in Wheat: Genomic Analysis and Demonstration of Its Role in Redox Homeostasis and Stress Resilience."],"pmcid":["PMC12688404"],"pubmed_authors":["Naz R","Hussain A","Nosheen A","Shier WT","Ghafoor MS","Yasmin H","Sajjad M","Keyani R"],"additional_accession":[]},"is_claimable":false,"name":"Nucleoredoxin 1 in Wheat: Genomic Analysis and Demonstration of Its Role in Redox Homeostasis and Stress Resilience.","description":"Nucleoredoxin 1 (NRX1), a member of the redoxin superfamily, plays a critical role in maintaining redox homeostasis and enhancing stress tolerance in plants. We employed integrated in silico analyses and CRISPR-Cas9-based genome editing to functionally characterize NRX1 in <i>Triticum aestivum</i> (wheat) responding to salinity and infection by <i>Puccinia striiformis</i>. We identified five NRX1 proteins coded by three homeologs, with each containing conserved thioredoxin-like domains and a Cys-rich C-terminal region. Sequence analysis predicted cytosolic and chloroplast localization, and promoter analysis predicted interaction with numerous <i>cis</i>-regulatory elements responsive to stress and hormones, including ABRE, MeJARE, and LTRE motifs. Expression profiling revealed significant ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T01:07:00.909Z","creation":"2026-05-24T03:11:46.781Z"},"accession":"S-EPMC12688404","cross_references":{"pubmed":["41377839"],"doi":["10.1002/pld3.70130"]}}