biostudies-literatureUnknown45(1)Buonsenso D<h4>Background</h4>Children with congenital cytomegalovirus (cCMV) can develop late-onset sensorineural hearing loss (LO-SNHL). In this study, we aim to assess the characteristics and predictors of LO-SNHL in infants with cCMV having normal hearing at the first neonatal assessment.<h4>Methods</h4>A retrospective study within the European Registry of Children with cCMV ( www.ccmvnet.org ) was performed. Included children had cCMV and a normal first audiological assessment by Auditory Brainstem Response (ABR). Late-onset hearing loss (LO-SNHL) is defined as the presence of sensorineural hearing loss after an initial normal hearing test. Hearing evaluation was performed at birth, at 6 months of age, and at least annually up to 6 years of age.<h4>Results</h4>Seven hundred twenty-one children wThe Pediatric infectious disease journal1-10https://www.ebi.ac.uk/biostudies/studies/S-EPMC12688458biostudies-literaturePrognostic Factors of Late-onset Hearing Loss in Infants With Congenital Cytomegalovirus and Normal Audiologic Assessment at Birth.PMC12688458Noguera Julian ACantero Garcia JFortuny Guasch CFidler KHerrero Perez SSophie Schaper AWilliams EGardiner EDouglas CAlfonso Rodriguez OSole LCharisi KFenoy MLanaghan CMontero Martin MButtcher MFalcon LCosta Lima SPagarkar WShears ACuadrado Perez IMajda-Stanislawska ESota Busselo IRios Barnes MMartin Lopez EHilali AVergadi EDavid EColino EChristie SCervantes ERojo PHawkins AJan WHeath PRico Pajares MIllan MLewandowski DMensalvas Ruiz AIGrazia Capretti MKottapalli SStorey SBaquero-Artigao FNavarri DGonzalez Bravo MNMoraleda CSivakumaran SHusada DMarin Cruz IHassan Hassan EHJones BPalasanthiran PGalan Del Rio PSchulze-Sturm UVogel TNunez Cuadros EPronzato Cuello FDel Mar Santos MLoizou CMavridi ASpyridakou CAlvarez Vallejo BRuiz Garcia MManian AAnsary AMoliner ESalome SFerguson WMalumbres Mde Vergas JUriarte Gutierrez HDuenas EVaquerizo Vaquerizo VPrieto LKruger RStefansson VCarrasco JAlonso Ojembrana AGoniotakis ICohen JBlazquez-Gamero DCarazo Gallego BVidal Moreso AEuropean Registry of Children with Congenital CMVBorgstein BPainoi PCroche Santander BPenner JFitzgerald AShan ARichmond VSanchez Mateos MFCrane RMartinez Lorenzo RMazur-Melewska KPerez Garcia ARementeria Radigales JIBadillo Navarro KDapena MSaavedra JSobowiec SPapaevangelou VCalavia Garsaball OEvans JFrattaroli PWellings LOhomoto de Morais CLi XKennedy VPocock LDrysdale SVillaverde Gonzalez SGarrote Llanos ESaavedra-Lozano JBhagwandas KToczylowski KJones LFoulon IMcMaster PAmor SEncinas Pardilla MBAbu Bakar AMuller JTerol Barrero PGiacomet VColino Gil ETagarro Garcia ARalph KVives Onos ISmyrnaios ASyridou GAlexe MRodrigo CDiez Martin RScott SArmoush SOana Gabriela FPAlvarez Breciano FEpalza CRumbao Aguirre JMGarofoli FGonce APerez Cid LGarcia Reymundo MMildred IVives-Onos ICrawley RBeceiro JPayne HKaragiannidou SKadambari SBuonsenso DEisen SKortsalioudaki CKaraoglu Asrak HBandi SGowin EBelen Jimenez AMontesdeoca Melian AOliver ALees ELampada CBringue Espuny XShah INavas AAlmarzooqi MTizzard SO'Brien KKane JElvegaard CFernandez Cooke EMartin JShah THolland SMartin RPedrero-Tome RMoliner Calderon ERamos Amador JTBuxmann HBaquero FMunoz Saa LOlabarrieta IMcCarthy KHector GCunarro ALopo Tuna MBolchova JFougere YNicolas Lopez MWalter SVanner NSmiskova DSoler Jde la Serna Martinez MVossen AIbrahim SReyes Millan BWills SVillaverde SReis Melo AJasmine MRaimondi FKopsidas IAmaryl JRincon Lopez EDel Castillo Navio EDel Rosal TThomas FParratt JDominic KBuciak ALindsey BLlana Martin IGlikman DLindsey KPitcher JAntonio Couceiro JHaras MCoroleu Lletget WKenny JGuri ANastouli EMarisco CFortuny CGarrido Martinez-Salazar FPajkrt DFerreras Antolin LCorredera Sanchez AMicol ADel Valle RCapozzi LFilgueira Posse AShackley FAlison KTsiatsiou OSelimaj VSulik ARomero Ramirez DFrick MAAlvarez de Blas AParsonson VSanchez Pintos PBarja Tur JGarcia Garcia MJSalvia DPinillos RRack-Hock AAgundez Reigosa BMignogna SChadwick RAraceli Hernandez DVila Bedmar SHafez LKachramanoglou CSen CAra FSoler Palacin PLyall HRoilides ETan NKeymeulen AWaltson FFieterna-Sperling CSoto BVernall RGutierrez Del Alamo CFCastells Vilella LLlorente MTzaki ABonil Martinez VDiaz FMendis SPollard LHayman MDhond KPedrero Tome RIsidro EMMPorta RTomlinson JMedina Claros AFSanz Rueda LCuadrado IAlexander EBamford AMuga Zuriarrain OCarreras Abad CKaiser-Labusch PLanglands JRios-Barnes MGuach BDoherty CGuillamo CGrande Tejada AMMotha RAra-Montojo FSmith CEscosa LMeir MAlvarez-Vallejo BLombardi GRodriguez-Molino PJanarthan SFreyne BfalsePrognostic Factors of Late-onset Hearing Loss in Infants With Congenital Cytomegalovirus and Normal Audiologic Assessment at Birth.<h4>Background</h4>Children with congenital cytomegalovirus (cCMV) can develop late-onset sensorineural hearing loss (LO-SNHL). In this study, we aim to assess the characteristics and predictors of LO-SNHL in infants with cCMV having normal hearing at the first neonatal assessment.<h4>Methods</h4>A retrospective study within the European Registry of Children with cCMV ( www.ccmvnet.org ) was performed. Included children had cCMV and a normal first audiological assessment by Auditory Brainstem Response (ABR). Late-onset hearing loss (LO-SNHL) is defined as the presence of sensorineural hearing loss after an initial normal hearing test. Hearing evaluation was performed at birth, at 6 months of age, and at least annually up to 6 years of age.<h4>Results</h4>Seven hundred twenty-one children w2026-01-01T00:00:00Z2026 Jan2026-06-11T05:11:03.02Z2026-06-11T03:08:18.852ZS-EPMC126884584083876410.1097/INF.0000000000004960