{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["37(1)"],"submitter":["Paulin TK"],"funding":["Lund University"],"pubmed_abstract":["<h4>Background</h4>Osteocalcin is a bone-specific protein involving many physiological processes, primarily bone turnover. Also closely related to the musculoskeletal system is the frailty syndrome.<h4>Aim</h4>To investigate if circulating osteocalcin levels and frailty are associated in the old, and in addition, if the presumed association is mediated through alterations in bone.<h4>Methods</h4>999 community-dwelling women from the OPRA (Osteoporosis Prospective Risk Assessment) cohort, all aged 75 years. Serum total osteocalcin was measured together with bone turnover markers PINP and CTX. An OPRA-adapted frailty index was applied. Association between osteocalcin and frailty was investigated using both logistic regression (osteocalcin quintiles Q<sub>low</sub>-Q<sub>high</sub>; Q<sub>1</"],"journal":["Aging clinical and experimental research"],"pagination":["342"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12689723"],"repository":["biostudies-literature"],"pubmed_title":["Osteocalcin and frailty among older women."],"pmcid":["PMC12689723"],"pubmed_authors":["Malmgren L","Ivaska KK","McGuigan FEA","Paulin TK","Bartosch P","Akesson KE"],"additional_accession":[]},"is_claimable":false,"name":"Osteocalcin and frailty among older women.","description":"<h4>Background</h4>Osteocalcin is a bone-specific protein involving many physiological processes, primarily bone turnover. Also closely related to the musculoskeletal system is the frailty syndrome.<h4>Aim</h4>To investigate if circulating osteocalcin levels and frailty are associated in the old, and in addition, if the presumed association is mediated through alterations in bone.<h4>Methods</h4>999 community-dwelling women from the OPRA (Osteoporosis Prospective Risk Assessment) cohort, all aged 75 years. Serum total osteocalcin was measured together with bone turnover markers PINP and CTX. An OPRA-adapted frailty index was applied. Association between osteocalcin and frailty was investigated using both logistic regression (osteocalcin quintiles Q<sub>low</sub>-Q<sub>high</sub>; Q<sub>1</","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-07T04:48:05.171Z","creation":"2026-06-07T03:06:04.664Z"},"accession":"S-EPMC12689723","cross_references":{"pubmed":["41364151"],"doi":["10.1007/s40520-025-03239-6"]}}