biostudies-literatureUnknown15Speijker LTD<h4>Introduction</h4>Prosthetic joint infections (PJI) affect 1-3% of prosthetic joint replacements, frequently linked to biofilm formation on implant surfaces. PJIs account for 13.0-31.3% of all revision surgeries. As treatment is not always successful, prevention remains critical. Currently, silver based antimicrobial coatings are justified in select high-risk arthroplasty cases, restricted to metal surfaces. An antibacterial silver multilayer coating (SML) has been developed for implant materials: titanium alloy (Ti) and cobalt-chromium-molybdenum alloy (CoCr), often used in hip or knee prostheses. The SML coating is intended for revision implants, which are often required due to infection related implant failure. This study investigates the antibacterial performance of the SML coating Frontiers in cellular and infection microbiology1707694https://www.ebi.ac.uk/biostudies/studies/S-EPMC12689873biostudies-literatureSilver multilayer coating on orthopedic implant material of different alloys and surfaces significantly reduces bacterial colonization.PMC12689873Speijker LTDArts JJDingemans JFechter JBargon Rvan Loo IHMSavelkoul PHMfalseSilver multilayer coating on orthopedic implant material of different alloys and surfaces significantly reduces bacterial colonization.<h4>Introduction</h4>Prosthetic joint infections (PJI) affect 1-3% of prosthetic joint replacements, frequently linked to biofilm formation on implant surfaces. PJIs account for 13.0-31.3% of all revision surgeries. As treatment is not always successful, prevention remains critical. Currently, silver based antimicrobial coatings are justified in select high-risk arthroplasty cases, restricted to metal surfaces. An antibacterial silver multilayer coating (SML) has been developed for implant materials: titanium alloy (Ti) and cobalt-chromium-molybdenum alloy (CoCr), often used in hip or knee prostheses. The SML coating is intended for revision implants, which are often required due to infection related implant failure. This study investigates the antibacterial performance of the SML coating 2025-01-01T00:00:00Z20252026-06-06T01:28:45.493Z2026-05-24T03:11:37.512ZS-EPMC126898734138385110.3389/fcimb.2025.1707694