biostudies-literatureUnknown13Larranaga I<h4>Introduction</h4>Patients with advanced chronic disease (ACD) experience transitions in their clinical stability, leading to increased healthcare resource use and costs. EU-funded ADLIFE digital intervention aimed to ensure their quality of life through individualised care plans, clinical decision-making support, and patient empowerment. This study assessed the impact and sustainability of ADLIFE.<h4>Materials and methods</h4>Target population included patients aged ≥55 years with heart failure (HF) and/or chronic obstructive pulmonary disease (COPD). First, a discrete event simulation (DES) model was developed using data from Osakidetza-Basque Health Service to represent the natural history of the disease. Second, ADLIFE intervention was implemented in four pilot sites: Spain, EnglandFrontiers in public health1682492https://www.ebi.ac.uk/biostudies/studies/S-EPMC12689975biostudies-literatureEvaluation of the epidemiological and economic impact of the ADLIFE intervention on medium- to long-term in patients with advanced chronic disease.PMC12689975Maguire RMar JMcCann LMiller MRobbins TPournik OGarton NFullaondo AArndt FGonzalez NGorostiza AZubeltzu BCaballero JSarigul BJuul NKTong CLarranaga ILaleci Erturkmen GBMoro AGrone OLopez BAguirre UVega RYilmaz GSwoboda ALyngholm Christensen RYuksel MADLIFE ConsortiumOrtega-Gil ABlomeke-Cammin JKalra DMorton AGarcia-Lorenzo BArvanitis TNPeake Ade la Torre JLevy GAznar-Baranda JIVishnevetsky OVerdoy DDichmann Sorknæs APanchal SAlayo ILilja MKoutsouradis KKaye Rde Manuel Keenoy EfalseEvaluation of the epidemiological and economic impact of the ADLIFE intervention on medium- to long-term in patients with advanced chronic disease.<h4>Introduction</h4>Patients with advanced chronic disease (ACD) experience transitions in their clinical stability, leading to increased healthcare resource use and costs. EU-funded ADLIFE digital intervention aimed to ensure their quality of life through individualised care plans, clinical decision-making support, and patient empowerment. This study assessed the impact and sustainability of ADLIFE.<h4>Materials and methods</h4>Target population included patients aged ≥55 years with heart failure (HF) and/or chronic obstructive pulmonary disease (COPD). First, a discrete event simulation (DES) model was developed using data from Osakidetza-Basque Health Service to represent the natural history of the disease. Second, ADLIFE intervention was implemented in four pilot sites: Spain, England2025-01-01T00:00:00Z20252026-05-26T11:06:35.984Z2026-05-24T03:11:18.294ZS-EPMC126899754138330510.3389/fpubh.2025.1682492