biostudies-literatureUnknown7(6)Kricheldorff JHigh-frequency deep brain stimulation of the subthalamic nucleus is used to treat motor symptoms in patients with Parkinson's disease. There is evidence that low-frequency stimulation in the range of 4-10 Hz may improve cognitive functions. This study investigates whether low-frequency deep brain stimulation of the subthalamic nucleus in the beta band (20 Hz) frequency can improve response inhibition in patients with Parkinson's disease. In a double-blind crossover design, <i>N</i> = 17 participants with Parkinson's disease performed four neuropsychological experiments, while on their usual dopaminergic medication, under no, standard high-frequency and 20 Hz beta low-frequency deep brain stimulation. The experiments consisted of a response selection task (response execution), a flanker tasBrain communicationsfcaf474https://www.ebi.ac.uk/biostudies/studies/S-EPMC12690201biostudies-literature20 Hz beta stimulation of the subthalamic nucleus improves response inhibition in Parkinson's disease.PMC12690201Sauer TKricheldorff JWitt Kfalse20 Hz beta stimulation of the subthalamic nucleus improves response inhibition in Parkinson's disease.High-frequency deep brain stimulation of the subthalamic nucleus is used to treat motor symptoms in patients with Parkinson's disease. There is evidence that low-frequency stimulation in the range of 4-10 Hz may improve cognitive functions. This study investigates whether low-frequency deep brain stimulation of the subthalamic nucleus in the beta band (20 Hz) frequency can improve response inhibition in patients with Parkinson's disease. In a double-blind crossover design, <i>N</i> = 17 participants with Parkinson's disease performed four neuropsychological experiments, while on their usual dopaminergic medication, under no, standard high-frequency and 20 Hz beta low-frequency deep brain stimulation. The experiments consisted of a response selection task (response execution), a flanker tas2025-01-01T00:00:00Z20252026-06-06T01:31:10.971Z2026-05-24T03:11:14.824ZS-EPMC126902014138364910.1093/braincomms/fcaf474