biostudies-literatureVelazquez ANational Science Foundatione70043https://www.ebi.ac.uk/biostudies/studies/S-EPMC12690271biostudies-literatureUnknown24(6)To optimize health, organisms must coordinate energy intake and expenditure and apportion related behaviors to appropriate times of day. In the fruit fly, Drosophila melanogaster, the SIFamide (SIFa) neuropeptide impacts multiple behavioral outputs important for energy regulation, including reproductive activity, sleep, and feeding. SIFa-expressing neurons receive convergent inputs from circadian and homeostatic brain regions and extend elaborate projections throughout the central nervous system. Consistent with this distribution pattern, the SIFa receptor (SIFaR) is widely expressed in the brain and ventral nerve cord, providing the anatomical substrate for SIFa signaling to influence a broad range of neuronal functions. To further explore the pleiotropic role of SIFa signaling in behavioGenes, brain, and behaviorThe Drosophila SIFamide Receptor Regulates Sleep and Feeding in a Time-Of-Day Specific Manner.PMC126902711942167Cavanaugh DJStepankovskaya ADe SBeaudouin AACusick MRTsibere OVelazquez ATidaback JAfalseThe Drosophila SIFamide Receptor Regulates Sleep and Feeding in a Time-Of-Day Specific Manner.To optimize health, organisms must coordinate energy intake and expenditure and apportion related behaviors to appropriate times of day. In the fruit fly, Drosophila melanogaster, the SIFamide (SIFa) neuropeptide impacts multiple behavioral outputs important for energy regulation, including reproductive activity, sleep, and feeding. SIFa-expressing neurons receive convergent inputs from circadian and homeostatic brain regions and extend elaborate projections throughout the central nervous system. Consistent with this distribution pattern, the SIFa receptor (SIFaR) is widely expressed in the brain and ventral nerve cord, providing the anatomical substrate for SIFa signaling to influence a broad range of neuronal functions. To further explore the pleiotropic role of SIFa signaling in behavio2025-01-01T00:00:00Z2025 Dec2026-06-07T04:58:03.393Z2026-06-07T03:07:22.76ZS-EPMC126902714136734110.1111/gbb.70043