{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Tomii D"],"pubmed_abstract":["<h4>Importance</h4>Aortic stenosis (AS) and obstructive coronary artery disease (CAD) often coexist, yet the impact of obstructive CAD on clinical and patient-reported outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) remains a subject of ongoing debate.<h4>Objectives</h4>To investigate the association of obstructive CAD with clinical outcomes and health status among patients with symptomatic severe AS undergoing TAVR.<h4>Design, setting, and participants</h4>This post hoc analysis of the investigator-initiated, multicenter SCOPE I (Safety and Efficacy of the Symetis ACURATE Neo/TF Compared to the Edwards SAPIEN 3 Bioprosthesis for Transcatheter Aortic Valve Implantation by Transfemoral Approach) randomized clinical trial was conducted at 20 tertiary heart cente"],"journal":["JAMA network open"],"pagination":["e2547111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12690430"],"repository":["biostudies-literature"],"pubmed_title":["Obstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement: A Post Hoc Analysis of the SCOPE I Randomized Clinical Trial."],"pmcid":["PMC12690430"],"pubmed_authors":["Kerber S","Redwood S","Conradi L","Thilo C","Walther T","Thiele H","Heg D","Windecker S","Linke A","Pilgrim T","Tomii D","Lanz J","Kim WK","Mollmann H","Toggweiler S","Joner M","Burgdorf C","Hilker M","Prendergast B"],"additional_accession":[]},"is_claimable":false,"name":"Obstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement: A Post Hoc Analysis of the SCOPE I Randomized Clinical Trial.","description":"<h4>Importance</h4>Aortic stenosis (AS) and obstructive coronary artery disease (CAD) often coexist, yet the impact of obstructive CAD on clinical and patient-reported outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) remains a subject of ongoing debate.<h4>Objectives</h4>To investigate the association of obstructive CAD with clinical outcomes and health status among patients with symptomatic severe AS undergoing TAVR.<h4>Design, setting, and participants</h4>This post hoc analysis of the investigator-initiated, multicenter SCOPE I (Safety and Efficacy of the Symetis ACURATE Neo/TF Compared to the Edwards SAPIEN 3 Bioprosthesis for Transcatheter Aortic Valve Implantation by Transfemoral Approach) randomized clinical trial was conducted at 20 tertiary heart cente","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-15T07:50:14.814Z","creation":"2026-07-01T03:07:59.774Z"},"accession":"S-EPMC12690430","cross_references":{"pubmed":["41364435"],"doi":["10.1001/jamanetworkopen.2025.47111"]}}