biostudies-literatureUnknown8(12)Tomii D<h4>Importance</h4>Aortic stenosis (AS) and obstructive coronary artery disease (CAD) often coexist, yet the impact of obstructive CAD on clinical and patient-reported outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) remains a subject of ongoing debate.<h4>Objectives</h4>To investigate the association of obstructive CAD with clinical outcomes and health status among patients with symptomatic severe AS undergoing TAVR.<h4>Design, setting, and participants</h4>This post hoc analysis of the investigator-initiated, multicenter SCOPE I (Safety and Efficacy of the Symetis ACURATE Neo/TF Compared to the Edwards SAPIEN 3 Bioprosthesis for Transcatheter Aortic Valve Implantation by Transfemoral Approach) randomized clinical trial was conducted at 20 tertiary heart centeJAMA network opene2547111https://www.ebi.ac.uk/biostudies/studies/S-EPMC12690430biostudies-literatureObstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement: A Post Hoc Analysis of the SCOPE I Randomized Clinical Trial.PMC12690430Kerber SRedwood SConradi LThilo CWalther TThiele HHeg DWindecker SLinke APilgrim TTomii DLanz JKim WKMollmann HToggweiler SJoner MBurgdorf CHilker MPrendergast BfalseObstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement: A Post Hoc Analysis of the SCOPE I Randomized Clinical Trial.<h4>Importance</h4>Aortic stenosis (AS) and obstructive coronary artery disease (CAD) often coexist, yet the impact of obstructive CAD on clinical and patient-reported outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) remains a subject of ongoing debate.<h4>Objectives</h4>To investigate the association of obstructive CAD with clinical outcomes and health status among patients with symptomatic severe AS undergoing TAVR.<h4>Design, setting, and participants</h4>This post hoc analysis of the investigator-initiated, multicenter SCOPE I (Safety and Efficacy of the Symetis ACURATE Neo/TF Compared to the Edwards SAPIEN 3 Bioprosthesis for Transcatheter Aortic Valve Implantation by Transfemoral Approach) randomized clinical trial was conducted at 20 tertiary heart cente2025-01-01T00:00:00Z2025 Dec2026-07-15T07:50:14.814Z2026-07-01T03:07:59.774ZS-EPMC126904304136443510.1001/jamanetworkopen.2025.47111