{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hendawy SHM"],"funding":["Agricultural Research Service - Pacific West Area, United States"],"pagination":["502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12690872"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["Background
The cattle fever tick, Rhipicephalus microplus, is found in tropical and subtropical regions worldwide. Infestations of this tick lead to significant economic losses for cattle producers and dairy farmers, and the ticks can transmit a variety of pathogens that cause diseases such as babesiosis, anaplasmosis and theileriosis. The proteins Bm86, AQP1, AQP2 and VgR are expressed in various tick tissues, including the gut, salivary glands and ovaries. These proteins regulate essential physiological processes, including water balance (AQP1, AQP2), reproduction (VgR) and cell membrane integrity (Bm86).Methods
Comprehensive bioinformatic and immunoinformatic analyses were conducted to evaluate Bm86, AQP1, AQP2 and VgR as potential vaccine targets against R. microplus. S"],"journal":["Parasites & vectors"],"pubmed_title":["Comparative immunoinformatic analysis of Rhipicephalus microplus cocktail vaccine targets."],"pmcid":["PMC12690872"],"funding_grant_id":["2090-32000-040-000-D"],"pubmed_authors":["Alzan HF","Hendawy SHM","Ueti MW"],"additional_accession":[]},"is_claimable":false,"name":"Comparative immunoinformatic analysis of Rhipicephalus microplus cocktail vaccine targets.","description":"Background
The cattle fever tick, Rhipicephalus microplus, is found in tropical and subtropical regions worldwide. Infestations of this tick lead to significant economic losses for cattle producers and dairy farmers, and the ticks can transmit a variety of pathogens that cause diseases such as babesiosis, anaplasmosis and theileriosis. The proteins Bm86, AQP1, AQP2 and VgR are expressed in various tick tissues, including the gut, salivary glands and ovaries. These proteins regulate essential physiological processes, including water balance (AQP1, AQP2), reproduction (VgR) and cell membrane integrity (Bm86).Methods
Comprehensive bioinformatic and immunoinformatic analyses were conducted to evaluate Bm86, AQP1, AQP2 and VgR as potential vaccine targets against R. microplus. S","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-07T04:57:38.828Z","creation":"2026-06-07T03:07:18.566Z"},"accession":"S-EPMC12690872","cross_references":{"pubmed":["41366802"],"doi":["10.1186/s13071-025-07109-y"]}}