biostudies-literatureUnknown25(1)Yang B<h4>Objectives</h4>To characterize the clinical features and identify determinants of mortality in patients with dermatomyositis (DM)-associated interstitial lung disease (ILD) who are positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, and to develop a prognostic prediction model.<h4>Methods</h4>Patients with DM-ILD were retrospectively analyzed. Mortality and baseline features were compared between antibody-positive and antibody-negative groups. In the antibody-positive subgroup, Kaplan-Meier survival curves were generated, and clinical characteristics were compared between survivors and non-survivors. Prognostic factors were identified by elastic-net Cox regression, and a nomogram was constructed. Model performance was evaluated using C-index, calibration, anBMC pulmonary medicine556https://www.ebi.ac.uk/biostudies/studies/S-EPMC12690898biostudies-literaturePrognostic factors and a nomogram for survival in anti-MDA5 antibody-positive dermatomyositis-associated interstitial lung disease.PMC12690898Tong ZYang BfalsePrognostic factors and a nomogram for survival in anti-MDA5 antibody-positive dermatomyositis-associated interstitial lung disease.<h4>Objectives</h4>To characterize the clinical features and identify determinants of mortality in patients with dermatomyositis (DM)-associated interstitial lung disease (ILD) who are positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, and to develop a prognostic prediction model.<h4>Methods</h4>Patients with DM-ILD were retrospectively analyzed. Mortality and baseline features were compared between antibody-positive and antibody-negative groups. In the antibody-positive subgroup, Kaplan-Meier survival curves were generated, and clinical characteristics were compared between survivors and non-survivors. Prognostic factors were identified by elastic-net Cox regression, and a nomogram was constructed. Model performance was evaluated using C-index, calibration, an2025-01-01T00:00:00Z2025 Dec2026-06-06T00:19:53.807Z2026-05-23T03:14:10.678ZS-EPMC126908984136636310.1186/s12890-025-04031-y