biostudies-literatureUnknown20(1)Abdelaziz O<h4>Background</h4>Perioperative glucocorticoids have been increasingly used in total knee arthroplasty (TKA) to optimize postoperative recovery, with prior evidence suggesting potential reductions in postoperative nausea and vomiting (PONV) in unilateral TKA. However, their safety and efficacy in primary bilateral total knee arthroplasty (BTKA) remain uncertain, particularly regarding pain relief, glycemic control, and PONV, given the greater surgical stress and limited BTKA-specific data. This systematic review and meta-analysis aimed to evaluate the impact of perioperative glucocorticoids on these outcomes in patients undergoing primary BTKA.<h4>Methods</h4>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Cochrane guidelines, a comprehensive Journal of orthopaedic surgery and research1066https://www.ebi.ac.uk/biostudies/studies/S-EPMC12690901biostudies-literatureImpact of perioperative glucocorticoids on glycemic control, PONV, and acute pain after primary bilateral total knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials.PMC12690901Zayed ZGAbdelaziz OKhalafallah MAHanafi MAElsayed AMfalseImpact of perioperative glucocorticoids on glycemic control, PONV, and acute pain after primary bilateral total knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials.<h4>Background</h4>Perioperative glucocorticoids have been increasingly used in total knee arthroplasty (TKA) to optimize postoperative recovery, with prior evidence suggesting potential reductions in postoperative nausea and vomiting (PONV) in unilateral TKA. However, their safety and efficacy in primary bilateral total knee arthroplasty (BTKA) remain uncertain, particularly regarding pain relief, glycemic control, and PONV, given the greater surgical stress and limited BTKA-specific data. This systematic review and meta-analysis aimed to evaluate the impact of perioperative glucocorticoids on these outcomes in patients undergoing primary BTKA.<h4>Methods</h4>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Cochrane guidelines, a comprehensive 2025-01-01T00:00:00Z2025 Dec2026-06-06T00:33:40.43Z2026-05-24T03:11:53.504ZS-EPMC126909014135072710.1186/s13018-025-06521-5